{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T17:43:15Z","timestamp":1782495795081,"version":"3.54.5"},"reference-count":40,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 CA008748"],"award-info":[{"award-number":["P30 CA008748"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Sinonasal mucosal melanoma (SNMM) is an aggressive cancer with high mortality. Identifying patients at risk of distant metastasis assists with management and prognostication. We aimed to define the relationship between volume, survival, and risk of distant metastases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective review of all patients with SNMM treated at a single institution over a 21\u2010year period was conducted. Tumor volume was calculated using cross\u2010sectional imaging and survival analysis was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010one patients were included. Tumor volume was predictive of local progression\u2010free survival (<jats:italic>P<\/jats:italic> =\u2009.03), distant metastases\u2010free survival (DMFS) (<jats:italic>P<\/jats:italic> =\u2009.002), and overall survival (OS) (<jats:italic>P<\/jats:italic> =\u2009.02). It was a better predictor than AJCC stage and T\u2010classification. Tumor volume equal to or greater than 5\u2009cm<jats:sup>3<\/jats:sup> was associated with a significantly worse DMFS and OS (<jats:italic>P<\/jats:italic> =\u2009.02 and .009, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Calculation of tumor volume assists in quantifying the risk of distant metastases and death in SNMM.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.26380","type":"journal-article","created":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T07:59:05Z","timestamp":1596268745000},"page":"3316-3325","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Primary tumor volume as a predictor of distant metastases and survival in patients with sinonasal mucosal melanoma"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9312-9409","authenticated-orcid":false,"given":"Stephanie","family":"Flukes","sequence":"first","affiliation":[{"name":"Department of Surgery Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2335-3581","authenticated-orcid":false,"given":"Shivangi","family":"Lohia","sequence":"additional","affiliation":[{"name":"Department of Surgery Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher A.","family":"Barker","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4496-906X","authenticated-orcid":false,"given":"Jennifer 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