{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T20:15:56Z","timestamp":1770668156770,"version":"3.49.0"},"reference-count":49,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,8,18]],"date-time":"2020-08-18T00:00:00Z","timestamp":1597708800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Little is known about immune\u2010related radiosensitivity in patients with squamous cell carcinoma of the larynx (SCC\u2010L) treated with radiation therapy (RT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively reviewed 91 patients with SCC\u2010L treated with RT or chemoradiation therapy and performed immunohistochemical examination to analyze PD\u2010L1 level on tumor cells, CD4<jats:sup>+<\/jats:sup> tumor\u2010infiltrating lymphocytes (TILs), CD8<jats:sup>+<\/jats:sup>TIL, and FOXP3<jats:sup>+<\/jats:sup>TIL using pretreated biopsy specimens. The association between these immune\u2010related parameters and radiosensitivity was evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Multivariate analyses showed that high CD8\/FOXP3 ratio combined with negative PD\u2010L1 expression was an independent and significant favorable predictive factor for local control, compared with the other groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We showed that high CD8\/FOXP3 ratio combined with negative PD\u2010L1 expression might be a useful biomarker of radiosensitivity in patients with SCC\u2010L receiving definitive RT. We propose that coassessment of CD8\/FOXP3 ratio and PD\u2010L1 expression level in tumor cells can help predict potential radiosensitivity in patients with SCC\u2010L.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.26416","type":"journal-article","created":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T02:52:16Z","timestamp":1598583136000},"page":"3518-3530","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Predictive value of <scp>CD8<\/scp>\/<scp>FOXP3<\/scp> ratio combined with <scp>PD\u2010L1<\/scp> expression for radiosensitivity in patients with squamous cell carcinoma of the larynx receiving definitive radiation therapy"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2414-7034","authenticated-orcid":false,"given":"Takeharu","family":"Ono","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Kurume University School of 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