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Concomitant cisplatin is given for T3\u2010T4a SCCs. Severe complications occur in 1% to 2% for Tis\u2010T2N0 and 10% for T3\u2010T4a SCCs. Patients with high\u2010volume T3\u2010T4 SCCs undergo total laryngectomy, neck dissection, and postoperative RT. Those with positive margins and\/or extranodal extension receive concomitant cisplatin. The likelihood of local\u2010regional control at 5\u2009years is 85% to 90%. Severe complications occur in 5% to 10%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>RT is a good treatment option for patients with Tis\u2010T2N0 and low\u2010volume T3\u2010T4a glottic SCCs. Patients with higher volume T3\u2010T4 cancers are best treated with surgery and postoperative RT.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.26419","type":"journal-article","created":{"date-parts":[[2020,9,14]],"date-time":"2020-09-14T07:50:30Z","timestamp":1600069830000},"page":"3558-3567","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Radiotherapy in the management of glottic squamous cell carcinoma"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6592-2810","authenticated-orcid":false,"given":"William M.","family":"Mendenhall","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology University of Florida College of Medicine  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0445-112X","authenticated-orcid":false,"given":"Primo\u017e","family":"Strojan","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Institute of Oncology  Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne W.M.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology University of Hong Kong Shenzhen Hospital, University of Hong Kong  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7956-6709","authenticated-orcid":false,"given":"Alessandra","family":"Rinaldo","sequence":"additional","affiliation":[{"name":"University of Udine School of Medicine  Udine Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avraham","family":"Eisbruch","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Michigan Medicine  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wai Tong","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology, LKS Faculty of Medicine The University of Hong Kong  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Smee","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology The Prince of Wales Cancer Centre  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8247-8002","authenticated-orcid":false,"given":"Alfio","family":"Ferlito","sequence":"additional","affiliation":[{"name":"International Head and Neck Scientific Group  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/107327481602300303"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.coc.0000242319.09994.78"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.coc.0000251368.57302.cc"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2007.05.036"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/COC.0b013e3181a3194f"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.08.066"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21261"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25189"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.10-3-215"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.43.6097"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.68.2336"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2012.11.002"},{"key":"e_1_2_7_14_1","volume-title":"AJCC Cancer Staging Handbook","author":"American Joint Committee on Cancer","year":"1997"},{"key":"e_1_2_7_15_1","volume-title":"AJCC Cancer Staging Handbook","author":"American Joint Committee on Cancer","year":"2002"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.coc.0000251403.54180.df"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2014.06.032"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13566-013-0131-6"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2018.03.034"},{"key":"e_1_2_7_20_1","first-page":"431","volume-title":"Management of Head and Neck: A Multidisciplinary Approach","author":"Million RR","year":"1994"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2017.10.016"},{"key":"e_1_2_7_22_1","volume-title":"Prescribing, Recording, and Reporting Photon Beam Therapy. 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