{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T12:29:24Z","timestamp":1779107364882,"version":"3.51.4"},"reference-count":38,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,8,21]],"date-time":"2020-08-21T00:00:00Z","timestamp":1597968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004829","name":"Department of Science and Technology of Sichuan Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004829","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004829","name":"Department of Science and Technology of Sichuan Province","doi-asserted-by":"publisher","award":["2019YJ0724"],"award-info":[{"award-number":["2019YJ0724"]}],"id":[{"id":"10.13039\/501100004829","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>It has been reported that the polyadenylate\u2010binding protein\u2010interacting protein 1 (PAIP1) pathway is closely connected with the progression of some malignant tumors. Here we examined the potential functional mechanism of PAIP1 in tongue squamous cell carcinoma (TSCC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>PAIP1 was knocked down in TSCC cell lines and proliferation and apoptosis in vitro analyzed. The molecular features of TSCC were determined using quantitative proteome and succinylome analyses. The results were confirmed in the mouse model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>PAIP1 promoted cell proliferation and inhibited apoptosis. Its knockdown decreased Ki67 and Pcna expressions and increased Bax\/Bcl2 index and Caspase\u20103 expression. Bioinformatics analysis for proteomics revealed that PAIP1 knockdown correlated with the changes in differential protein expression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Upregulation of PAIP1 induces cell proliferation and inhibits apoptosis in TSCC; PAIP1 might be a diagnostic biomarker and a significant drug target.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.26423","type":"journal-article","created":{"date-parts":[[2020,8,22]],"date-time":"2020-08-22T07:45:56Z","timestamp":1598082356000},"page":"3623-3637","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effects of inducing apoptosis and inhibiting proliferation of <scp>siRNA<\/scp> on polyadenylate\u2010binding protein\u2010interacting protein 1 in tongue cell carcinoma"],"prefix":"10.1002","volume":"42","author":[{"given":"Huixu","family":"Xie","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral Diseases, Department of Head and Neck Oncology, National Clinical Research Center for Oral Diseases West China Hospital of Stomatology, Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases, Department of Head and Neck Oncology, National Clinical Research Center for Oral Diseases West China Hospital of Stomatology, Sichuan University  Chengdu China"},{"name":"Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1500-590X","authenticated-orcid":false,"given":"Qin","family":"Hu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases, Department of Head and Neck Oncology, National Clinical Research Center for Oral Diseases West China Hospital of Stomatology, Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingqi","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Pharmacology West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyi","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases, Department of Head and Neck Oncology, National Clinical Research Center for Oral Diseases West China Hospital of Stomatology, Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liming","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pharmacology West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Longjiang","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases, Department of Head and Neck Oncology, National Clinical Research Center for Oral Diseases West China Hospital of Stomatology, Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,8,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20107"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21384"},{"key":"e_1_2_7_4_1","first-page":"411","article-title":"Clinical analysis of patient in cN0 OSCC and level IIb lymph nodes metastasis","volume":"26","author":"Fan JH","year":"2016","journal-title":"J Oral Maxil Surg"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23278"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/33198"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(01)00167-8"},{"key":"e_1_2_7_8_1","first-page":"1","article-title":"Analyses of ribosome distribution during in vitro translation","volume":"77","author":"Wolin SL","year":"1998","journal-title":"Meth Mol Biol"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.01.042"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-7-58"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2018.544"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2007.05.044"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2017.10.037"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2019.01.017"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2009.160"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-012-9349-9"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00738-08"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2013.06.019"},{"key":"e_1_2_7_19_1","first-page":"447","volume-title":"Translational Control of Gene Expression","author":"Sachs A","year":"2009"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1996.0065"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.22.11.3769-3782.2002"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1618"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2018.11.017"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.520429"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acthis.2016.05.002"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-013-2560-8"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2011.06.017"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.7.4666"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2017.06.190"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.281.5381.1312"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3893"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20070679"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-0302"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.200300550"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.24489"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2015.3090"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1202088"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-2988"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2018.12.007"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.26423","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hed.26423","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.26423","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T07:53:34Z","timestamp":1693727614000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.26423"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,21]]},"references-count":38,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["10.1002\/hed.26423"],"URL":"https:\/\/doi.org\/10.1002\/hed.26423","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,21]]},"assertion":[{"value":"2019-11-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}