{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T07:02:31Z","timestamp":1763535751581,"version":"3.40.5"},"reference-count":19,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,8,19]],"date-time":"2020-08-19T00:00:00Z","timestamp":1597795200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Patient Reported Outcome (PRO) data comparing bolus (B\u2010CP) with weekly (W\u2010CP) cisplatin concurrent with radiation are lacking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective study comparing PRO among 99 patients with head and neck radiation, 26% who received concurrent B\u2010CP and 73% treated with W\u2010CP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>W\u2010CP patients had a higher Charlson comorbidity index (CCI) (<jats:italic>P<\/jats:italic> = .004). There were no differences in median cisplatin dose, PROs, percutaneous endoscopic gastrostomy (PEG) dependence or hospitalization between arms. Patients with a greater decline in their self\u2010reported dysphagia score were more often PEG dependent at the end of radiation therapy (<jats:italic>P<\/jats:italic> = .03). There was also a trend toward PEG dependence with a higher maximum dysphagia score and greater change in aspiration score (<jats:italic>P<\/jats:italic> = .06). The maximum decline in white cell count and absolute neutrophil count were greater in the W\u2010CP group (<jats:italic>P<\/jats:italic> = .04, <jats:italic>P<\/jats:italic> = .01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Both B\u2010CP and W\u2010CP are well tolerated. PROs do not suggest a benefit to W\u2010CP.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.26432","type":"journal-article","created":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T02:52:16Z","timestamp":1598583136000},"page":"3670-3677","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Patient reported outcomes in patients with head and neck cancer treated with concurrent chemoradiation with weekly versus bolus cisplatin"],"prefix":"10.1002","volume":"42","author":[{"given":"Mona","family":"Arbab","sequence":"first","affiliation":[{"name":"Brigham and Women's Hospital  Boston Massachusetts USA"},{"name":"Department of Radiation Oncology Indiana University  Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010Hui","family":"Chen","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital\/Dana\u2010Farber Cancer Institute  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shana","family":"Criscitiello","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital\/Dana\u2010Farber Cancer Institute  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason","family":"Glass","sequence":"additional","affiliation":[{"name":"Dana\u2010Farber Cancer Institute  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo Ann","family":"Fugazzotto","sequence":"additional","affiliation":[{"name":"Dana\u2010Farber Cancer Institute  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph H.","family":"Killoran","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glenn","family":"Hanna","sequence":"additional","affiliation":[{"name":"Brigham and Women's 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