{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T12:43:31Z","timestamp":1790340211341,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,9,14]],"date-time":"2020-09-14T00:00:00Z","timestamp":1600041600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Mucosal melanoma (MM) is a rare condition with a poor prognosis. Surgery is the corner stone of treatment, however, radiotherapy has been commonly employed as a treatment strategy and recent studies suggesting that survival outcomes may be improving are emerging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic review and meta\u2010analysis comparing risk ratios of radiotherapy and surgery and radiotherapy (SRT) with surgery for 5\u2010year overall survival, local recurrence and distant metastasis in head and neck mucosal melanoma (HNMM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      SRT has a lower risk of death compared to surgery [RR 0.93 [95% CI = 0.87, 0.98] (\n                      <jats:italic>P<\/jats:italic>\n                      = .01)] and a reduced risk of local recurrence [RR 0.63 [95% CI = 0.48, 0.82] (\n                      <jats:italic>P<\/jats:italic>\n                      = .005)]. SRT has no effect on distant metastasis. Radiotherapy has worse survival when compared to surgery [RR 1.2 [95% CI = 1.03, 1.33] (\n                      <jats:italic>P<\/jats:italic>\n                      = .0006)].\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>SRT confers a moderate survival advantage in HNMM compared to surgery. This is most likely secondary to reduced local recurrence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.26470","type":"journal-article","created":{"date-parts":[[2020,12,8]],"date-time":"2020-12-08T22:55:33Z","timestamp":1607468133000},"page":"323-333","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["The effectiveness of radiotherapy in the treatment of head and neck mucosal melanoma: Systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8520-3469","authenticated-orcid":false,"given":"Marc C.","family":"Grant\u2010Freemantle","sequence":"first","affiliation":[{"name":"School of Medicine University College Cork  Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Billy","family":"Lane O'Neill","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Cork University Hospital  Cork 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