{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T17:17:58Z","timestamp":1787764678051,"version":"build-2784847793"},"reference-count":58,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,10,15]],"date-time":"2020-10-15T00:00:00Z","timestamp":1602720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We aimed to compare unstimulated saliva flow using 3\u2010minute modified Schirmer test (MST) following bilateral vs unilateral radiotherapy (RT) in oropharyngeal carcinoma (OPC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We reviewed OPC patients treated with definitive intensity\u2010modulated radiation therapy (IMRT) between 2011 and 2017. MST was measured at baseline, 1\u2010\/6\u2010\/12\u2010\/24\u2010month post\u2010RT. MST values were compared between bilateral\u2010RT vs unilateral\u2010RT groups. Multivariable logistic regression analysis (MVA) identified predictors of hyposalivation (MST\u2009&lt;\u200925\u2009mm).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Total 498 bilateral\u2010RT and 36 unilateral\u2010RT patients were eligible. The MST values at 1\u2010\/6\u2010\/12\u2010\/24\u2010month post\u2010RT were all significantly reduced from baseline for the entire cohort. Baseline unilateral\u2010RT and bilateral\u2010RT MST values (in mm) were similar (<jats:italic>P<\/jats:italic> = .2), but much higher for unilateral\u2010RT 1\u2010month (mean: 19.1 vs 13.0, <jats:italic>P<\/jats:italic> = .03), 6\u2010month (20.5 vs 9.3, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001), 12\u2010month (20.1 vs 11.9, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.01), and 24\u2010month post\u2010RT (22.2 vs 13.9, <jats:italic>P<\/jats:italic> = .04). MVA confirmed that unilateral RT reduced the likelihood of hyposalivation vs bilateral RT (OR 2.36, <jats:italic>P<\/jats:italic> = .006).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Unilateral RT reduces unstimulated salivary flow in OPC patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.26496","type":"journal-article","created":{"date-parts":[[2020,10,15]],"date-time":"2020-10-15T10:48:50Z","timestamp":1602758930000},"page":"456-466","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Short\u2010term and long\u2010term unstimulated saliva flow following unilateral vs bilateral radiotherapy for oropharyngeal carcinoma"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8072-4388","authenticated-orcid":false,"given":"Shao Hui","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Princess Margaret Cancer 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