{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T05:26:13Z","timestamp":1782365173374,"version":"3.54.5"},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,10,13]],"date-time":"2020-10-13T00:00:00Z","timestamp":1602547200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To assess the impact of treatment delay on survival of oral\/oropharyngeal cancer (OSCC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We followed 5743 OSCCs between 2004 and 2009 from a population\u2010based screening program and ascertained death until the end of 2012.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The hazard ratios (HRs) of mortality from OSCC were 1.46 (1.30\u20101.65) and 1.18 (1.04\u20101.33) in univariable and multivariable analyses, respectively, for treatment delay longer than 6\u2009weeks compared with that shorter than 3\u2009weeks. The corresponding figures were 1.12 (1.01\u20101.24) and 1.00 (0.91\u20101.11) for treatment delay between 3 and 6\u2009weeks. Advancing age (1.01), higher stage (stage II: 1.84, stage III: 2.97, stage IV: 6.33), cancer in tongue (1.37), or hard palate (1.63) had higher HR of mortality (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05). However, treatment at medical center had a lower mortality (0.83, 0.75\u20100.91) than local\/regional hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Treatment delay longer than 6\u2009weeks for OSCCs detected via a population\u2010based screening program had unfavorable survival.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.26504","type":"journal-article","created":{"date-parts":[[2020,10,13]],"date-time":"2020-10-13T08:08:06Z","timestamp":1602576486000},"page":"473-484","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Impact of treatment delay on survival of oral\/oropharyngeal cancers: Results of a nationwide screening program"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1640-2920","authenticated-orcid":false,"given":"William Wang\u2010Yu","family":"Su","sequence":"first","affiliation":[{"name":"Division of Otorhinolaryngology\u2010Head &amp; Neck Surgery Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation  New Taipei City Taiwan"},{"name":"School of Medicine Tzu Chi University  Hualien Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Huah","family":"Lee","sequence":"additional","affiliation":[{"name":"Institute of Epidemiology and Preventive Medicine, College of Public Health National Taiwan University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy Ming\u2010Fang","family":"Yen","sequence":"additional","affiliation":[{"name":"School of Oral Hygiene, College of Oral Medicine Taipei Medical University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9750-3015","authenticated-orcid":false,"given":"Sam Li\u2010Sheng","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Oral Hygiene, College of Oral Medicine Taipei Medical University  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