{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T22:55:57Z","timestamp":1788648957134,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,10,7]],"date-time":"2020-10-07T00:00:00Z","timestamp":1602028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Human papillomavirus (HPV)\u2010positive oropharyngeal squamous cell carcinoma (OPSCC) have better prognosis and treatment response compared to HPV\u2010negative OPSCC. This study aims to noninvasively predict HPV status of OPSCC using clinical and\/or radiological variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seventy\u2010seven magnetic resonance radiomic features were extracted from T1\u2010weighted postcontrast images of the primary tumor of 153 patients. Logistic regression models were created to predict HPV status, determined with immunohistochemistry, based on clinical variables, radiomic features, and its combination. Model performance was evaluated using area under the curve (AUC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Model performance showed AUCs of 0.794, 0.764, and 0.871 for the clinical, radiomic, and combined models, respectively. Smoking, higher T\u2010classification (T3 and T4), larger, less round, and heterogeneous tumors were associated with HPV\u2010negative tumors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Models based on clinical variables and\/or radiomic tumor features can predict HPV status in OPSCC patients with good performance and can be considered when HPV testing is not available.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.26505","type":"journal-article","created":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T05:48:41Z","timestamp":1602136121000},"page":"485-495","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Clinical variables and magnetic resonance imaging\u2010based radiomics predict human papillomavirus status of oropharyngeal cancer"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0194-1465","authenticated-orcid":false,"given":"Paula","family":"Bos","sequence":"first","affiliation":[{"name":"Department of Radiology The Netherlands Cancer Institute  Amsterdam The Netherlands"},{"name":"Department of Head and Neck Oncology and Surgery The Netherlands Cancer Institute  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6338-6743","authenticated-orcid":false,"given":"Michiel W. 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