{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T19:05:37Z","timestamp":1782932737046,"version":"3.54.5"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T00:00:00Z","timestamp":1603756800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["689715"],"award-info":[{"award-number":["689715"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Despite advances in treatments, 30% to 50% of stage III\u2010IV head and neck squamous cell carcinoma (HNSCC) patients relapse within 2\u2009years after treatment. The Big Data to Decide (BD2Decide) project aimed to build a database for prognostic prediction modeling.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Stage III\u2010IV HNSCC patients with locoregionally advanced HNSCC treated with curative intent (1537) were included. Whole transcriptomics and radiomics analyses were performed using pretreatment tumor samples and computed tomography\/magnetic resonance imaging scans, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The entire cohort was composed of 71% male (1097)and 29% female (440): oral cavity (429, 28%), oropharynx (624, 41%), larynx (314, 20%), and hypopharynx (170, 11%); median follow\u2010up 50.5 months. Transcriptomics and imaging data were available for 1284 (83%) and 1239 (80%) cases, respectively; 1047 (68%) patients shared both.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This annotated database represents the HNSCC largest available repository and will enable to develop\/validate a decision support system integrating multiscale data to explore through classical and machine learning models their prognostic role.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.26515","type":"journal-article","created":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T08:47:38Z","timestamp":1603788458000},"page":"601-612","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Development of a multiomics database for personalized prognostic forecasting in head and neck cancer: The Big Data to Decide <scp>EU<\/scp> Project"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1294-6859","authenticated-orcid":false,"given":"Stefano","family":"Cavalieri","sequence":"first","affiliation":[{"name":"Head and Neck Medical Oncology Unit Fondazione IRCCS Istituto Nazionale dei Tumori di Milano  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loris","family":"De Cecco","sequence":"additional","affiliation":[{"name":"Integrated Biology Platform, Department of Applied Research and Technology Development Fondazione IRCCS Istituto Nazionale dei Tumori di Milano  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruud H.","family":"Brakenhoff","sequence":"additional","affiliation":[{"name":"Vrije Universiteit Amsterdam, Otolaryngology\/Head and Neck Surgery Amsterdam UMC, Cancer Center Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara Serena","family":"Serafini","sequence":"additional","affiliation":[{"name":"Integrated Biology Platform, Department of Applied Research and Technology Development Fondazione IRCCS Istituto Nazionale dei Tumori di Milano  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvana","family":"Canevari","sequence":"additional","affiliation":[{"name":"Fondazione IRCCS Istituto Nazionale dei Tumori di Milano. Milan  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Rossi","sequence":"additional","affiliation":[{"name":"Unit of Maxillofacial Surgery, Department of Medicine and Surgery University of Parma \u2013 University Hospital of Parma  Parma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Lanfranco","sequence":"additional","affiliation":[{"name":"Unit of Maxillofacial Surgery, Department of Medicine and Surgery University of Parma \u2013 University Hospital of Parma  Parma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank J. P.","family":"Hoebers","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology (MAASTRO), Research Institute GROW Maastricht University  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederik W. R.","family":"Wesseling","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology (MAASTRO), Research Institute GROW Maastricht University  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Keek","sequence":"additional","affiliation":[{"name":"The D\u2010Lab, Department of Precision Medicine, GROW\u2010 School for Oncology Maastricht University Medical Center  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrin","family":"Scheckenbach","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Medical Faculty Heinrich Heine University D\u00fcsseldorf  D\u00fcsseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Mattavelli","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery Spedali Civili di Brescia and University of Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery Ulm University Medical Center  Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"L\u00f3pez P\u00e9rez","sequence":"additional","affiliation":[{"name":"Life Supporting Technologies, Photonics Technology and Bioengineering Department, School of Telecommunication Engineering Universidad Polit\u00e9cnica de Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Fico","sequence":"additional","affiliation":[{"name":"Life Supporting Technologies, Photonics Technology and Bioengineering Department, School of Telecommunication Engineering Universidad Polit\u00e9cnica de Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Bologna","sequence":"additional","affiliation":[{"name":"Department of Electronics, Information and Bioengineering (DEIB) Politecnico di Milano Politecnico di Milano  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Nauta","sequence":"additional","affiliation":[{"name":"Vrije Universiteit Amsterdam, Otolaryngology\/Head and Neck Surgery Amsterdam UMC, Cancer Center Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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