{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T01:00:40Z","timestamp":1782435640200,"version":"3.54.5"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,11,5]],"date-time":"2020-11-05T00:00:00Z","timestamp":1604534400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hypoxia is a negative prognostic factor in head and neck squamous cell carcinomas. Under hypoxia, the hypoxia\u2010inducible factor (HIF)\u20101a transcription factor is overexpressed. We investigated whether there were site differences in HIF\u20101a expression and its effect on patient outcomes per subsite.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design\/Method<\/jats:title><jats:p>A total of 941 patients with HNSCC in the squamous cell carcinoma of the oropharynx (OPSCC, n = 302), oral cavity (OSCC, n = 391), or larynx (LSCC, n = 248) were included. Expression of HIF\u20101a in tissue samples was investigated using immunohistochemistry. Overall survival (OS), disease\u2010free survival (DFS), and locoregional control (LRC) were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>HIF\u20101a expression was higher in OSCC than in LSCC and OPSCC. High HIF\u20101a expression led to worse prognosis in OPSCC (OS <jats:italic>P<\/jats:italic> = .029, DFS <jats:italic>P<\/jats:italic> = .085) and LSCC (OS <jats:italic>P<\/jats:italic> = .041, DFS <jats:italic>P<\/jats:italic> = .011) and better in OSCC (OS <jats:italic>P<\/jats:italic> = .055, DFS <jats:italic>P<\/jats:italic> = .012). There was no association between HIF\u20101a and LRC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>High HIF\u20101a expression is related to poor outcome in OPSCC and LSCC and better outcome in OSCC.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.26530","type":"journal-article","created":{"date-parts":[[2020,11,6]],"date-time":"2020-11-06T03:56:02Z","timestamp":1604634962000},"page":"745-756","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["HIF\u20101a expression and differential effects on survival in patients with oral cavity, larynx, and oropharynx squamous cell carcinomas"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4288-0803","authenticated-orcid":false,"given":"Justin E.","family":"Swartz","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology \u2013 Head and Neck Surgery University Medical Center Utrecht  Utrecht Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inge","family":"Wegner","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology \u2013 Head and Neck Surgery University Medical Center Utrecht  Utrecht Netherlands"},{"name":"Department of Head and Neck Surgical Oncology University Medical Center Utrecht  Utrecht Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6952-8135","authenticated-orcid":false,"given":"Rob","family":"Noorlag","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery University Medical Center Utrecht  Utrecht Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline M. W.","family":"van Kempen","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology \u2013 Head and Neck Surgery University Medical Center Utrecht  Utrecht Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J. J.","family":"van Es","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgical Oncology University Medical Center Utrecht  Utrecht Netherlands"},{"name":"Department of Oral and Maxillofacial Surgery University Medical Center Utrecht  Utrecht Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7128-5814","authenticated-orcid":false,"given":"Remco","family":"de Bree","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgical Oncology University Medical Center Utrecht  Utrecht Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan M. 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