{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T09:39:33Z","timestamp":1789205973279,"version":"build-2803163510"},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,11,9]],"date-time":"2020-11-09T00:00:00Z","timestamp":1604880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The prognostic importance of intraparotid lymph node metastasis (P+) in patients with primary parotid gland carcinoma is unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Nineteen retrospective and noncomparative cohort studies, published between 1992 and 2020, met the inclusion criteria and included 2202 patients for this systematic review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The pooled prevalence of the P in adult patients in the unselected studies was 24.10% (95% confidence interval = 17.95\u201030.25). The number of P+ lymph nodes per patient was counted in only three studies and ranged from 1 to 11. The 5\u2010year recurrence\u2010free survival rate based on Kaplan\u2010Meier analysis varied from 83% to 88% in P\u2212 patients compared to 36% to 54% in P+ patients. The average hazard ratio for tumor recurrence in patients with P+ compared to P\u2212 was 2.67\u2009\u00b1\u20090.58.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>P+ is an independent negative prognostic factor in primary parotid gland cancer and should be included into the treatment planning.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.26541","type":"journal-article","created":{"date-parts":[[2020,11,10]],"date-time":"2020-11-10T05:33:41Z","timestamp":1604986421000},"page":"997-1008","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Prognostic role of intraparotid lymph node metastasis in primary parotid cancer: Systematic review"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9671-0784","authenticated-orcid":false,"given":"Orlando","family":"Guntinas\u2010Lichius","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Jena University Hospital, Friedrich Schiller University  Jena Germany"},{"name":"Facial Nerve Center Jena University Hospital, Friedrich Schiller University  Jena Germany"},{"name":"Multidisciplinary Salivary Gland Society  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jovanna","family":"Thielker","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Jena University Hospital, Friedrich Schiller University  Jena Germany"},{"name":"Facial Nerve Center Jena University Hospital, Friedrich Schiller University  Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3255-8960","authenticated-orcid":false,"given":"K. 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