{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T04:06:15Z","timestamp":1792037175844,"version":"4.4.0"},"reference-count":53,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,11,21]],"date-time":"2020-11-21T00:00:00Z","timestamp":1605916800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Liposarcomas are the second most common type of soft tissue sarcomas. Typically, myxoid liposarcomas have a metastatic rate of 10%, usually involving the retroperitoneal space, abdomen, and spine. Metastasis to the thyroid is extremely rare.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design\/Method<\/jats:title><jats:p>A 62\u2010year\u2010old male with a history of metastatic myxoid liposarcoma in his right thigh presented to our clinic for evaluation of a thyroid nodule incidentally identified on a CT scan. A subsequent FNA biopsy was suggestive of a metastatic liposarcoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The patient underwent a left thyroid lobectomy and final pathology confirmed a grade II\/III metastatic myxoid liposarcoma that measured 3.3 cm. The patient tolerated the procedure well.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our case highlights the role of a patient's medical history when evaluating thyroid nodules to optimize accurate diagnosis, as liposarcomas do not typically metastasize to the thyroid. We also provide an updated review of the literature on all cases of metastatic sarcomas to the thyroid.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.26552","type":"journal-article","created":{"date-parts":[[2020,11,21]],"date-time":"2020-11-21T18:33:24Z","timestamp":1605983604000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Rare case of metastatic liposarcoma to the thyroid gland and a review of the literature of metastatic sarcomas to the thyroid"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2094-475X","authenticated-orcid":false,"given":"Monica H.","family":"Xing","sequence":"first","affiliation":[{"name":"The Thyroid, Head and Neck Cancer (THANC) Foundation  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Mundi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Icahn School of Medicine at Mount Sinai Hospital, Mount Sinai Beth Israel  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aparna","family":"Govindan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Icahn School of Medicine at Mount Sinai Hospital, Mount Sinai Beth Israel  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azita","family":"Khorsandi","sequence":"additional","affiliation":[{"name":"Department of Radiology New York Eye and Ear Infirmary  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Brandwein\u2010Weber","sequence":"additional","affiliation":[{"name":"Department of Pathology Icahn School of Medicine at Mount Sinai Hospital  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ammar","family":"Matloob","sequence":"additional","affiliation":[{"name":"Department of Pathology Icahn School of Medicine at Mount Sinai Hospital  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bobby","family":"Liaw","sequence":"additional","affiliation":[{"name":"Department of Hematology\u2010Oncology Icahn School of Medicine at Mount Sinai Hospital, Mount Sinai Beth Israel  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark L.","family":"Urken","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Icahn School of Medicine at Mount Sinai Hospital, Mount Sinai Beth Israel  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-018-4226-8"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.soc.2016.05.007"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.74.9598"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12022-017-9475-6"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2010.0154"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12022-013-9257-8"},{"issue":"3","key":"e_1_2_6_8_1","first-page":"242","article-title":"Metastatic infiltration of the thyroid gland causing hypothyroidism","volume":"35","author":"Sirota DK","year":"1968","journal-title":"J Mt Sinai Hosp N Y"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-013-3282-1"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.12548"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.4065\/82.11.1409"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-61779-062-1_11"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr\/29206613"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003072-200201000-00002"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20024"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215106000867"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12957-018-1370-1"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2004.03.012"},{"issue":"11","key":"e_1_2_6_19_1","first-page":"643","article-title":"An unusual metastasis of a chondrosarcoma in the thyroid gland","volume":"159","author":"Bakx PA","year":"1993","journal-title":"Eur J Surg"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/1752-1947-8-157"},{"key":"e_1_2_6_21_1","first-page":"53","article-title":"M\u00e9tastase intrathyro\u00efdienne d'un chondrosarcome","volume":"87","author":"El Otmany AH","year":"2001","journal-title":"M\u00e9decine Du Maghreb"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12022-014-9351-6"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjorl.2015.09.008"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000018043"},{"issue":"2","key":"e_1_2_6_25_1","first-page":"174","article-title":"Metastasis of leiomyosarcoma to the thyroid","volume":"118","author":"Deng XR","year":"2005","journal-title":"Chin Med J (Engl)"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2007.0082"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.remn.2016.09.002"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1438.2006.00201.x"},{"key":"e_1_2_6_29_1","article-title":"A rare case of uterine leiomyosarcoma with metastasis to the thyroid gland","volume":"2020","author":"Irizarry\u2010Villafane G","year":"2020","journal-title":"Case Rep Endocrinol"},{"issue":"1","key":"e_1_2_6_30_1","first-page":"37","article-title":"Metastatic tumors of the thyroid gland: a study of 79 cases in Chinese patients","volume":"122","author":"Lam KY","year":"1998","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(02)02191-9"},{"issue":"4","key":"e_1_2_6_32_1","first-page":"307","article-title":"Leiomyosarcoma metastatic to the thyroid diagnosed by fine needle aspiration cytology","volume":"60","author":"Nemenqani D","year":"2010","journal-title":"J Pak Med Assoc"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ando.2011.06.001"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.3803\/EnM.2013.28.1.46"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599816629632"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2005.02206.x"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2018.07.020"},{"issue":"2","key":"e_1_2_6_38_1","first-page":"111","article-title":"Metastatic angiosarcoma to the thyroid","volume":"126","author":"Eng SP","year":"2005","journal-title":"Rev Laryngol Otol Rhinol (Bord)"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.5858\/2002-126-1233-PTMTTH"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/659654"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0000000000002004"},{"issue":"1","key":"e_1_2_6_42_1","first-page":"51","article-title":"Metastasis to the thyroid gland; unusual site of metastasis","volume":"1","author":"Saber A","year":"2007","journal-title":"Gulf J Oncolog"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0000000000000552"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.4103\/0377-4929.162870"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003072-198708000-00015"},{"issue":"2","key":"e_1_2_6_46_1","first-page":"359","article-title":"Thyroid regional metastasis from a giant cell malignant fibrous histiocytoma of the larynx in a patient with history of trichinellosis and tuberculosis","volume":"51","author":"Lichiardopol C","year":"2010","journal-title":"Rom J Morphol Embryol"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1080\/09513590701560733"},{"issue":"12","key":"e_1_2_6_48_1","first-page":"1342","article-title":"Metastasis of a caecal neuroendocrine carcinoma to the thyroid gland","volume":"58","author":"Papi G","year":"2005","journal-title":"J Clin Pathol"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1159\/000325631"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23311"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1159\/000486333"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/8928706"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/8029157"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/os.12566"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.26552","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hed.26552","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.26552","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T05:09:12Z","timestamp":1748840952000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.26552"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,21]]},"references-count":53,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["10.1002\/hed.26552"],"URL":"https:\/\/doi.org\/10.1002\/hed.26552","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,21]]},"assertion":[{"value":"2020-10-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}