{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:09:50Z","timestamp":1787166590461,"version":"build-2736575974"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,2,2]],"date-time":"2021-02-02T00:00:00Z","timestamp":1612224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Nomograms applying the 8th edition of the TNM staging system aimed at predicting overall (OS), disease\u2010specific (DSS), locoregional recurrence\u2010free (LRRFS) and distant recurrence\u2010free survivals (DRFS) for oral tongue squamous cell carcinoma (OTSCC) are still lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A training cohort of 438 patients with OTSCC was retrospectively enrolled from a single institution. An external validation set of 287 patients was retrieved from two independent institutions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Internal validation of the multivariable models for OS, DSS, DRFS and LRRFS showed a good calibration and discrimination results with optimism\u2010corrected c\u2010indices of 0.74, 0.75, 0.77 and 0.70, respectively. The external validation confirmed the good performance of OS, DSS and DRFS models (c\u2010index 0.73 and 0.77, and 0.73, respectively) and a fair performance of the LRRFS model (c\u2010index 0.58).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The nomograms herein presented can be implemented as useful tools for prediction of OS, DSS, DRFS and LRRFS in OTSCC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.26554","type":"journal-article","created":{"date-parts":[[2021,2,5]],"date-time":"2021-02-05T23:26:02Z","timestamp":1612567562000},"page":"1043-1055","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Predictive nomograms for oral tongue squamous cell carcinoma applying the American Joint Committee on Cancer\/Union Internationale Contre le Cancer 8th edition staging system"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7404-1452","authenticated-orcid":false,"given":"Deepak","family":"Balasubramanian","sequence":"first","affiliation":[{"name":"Department of Head and Neck Oncology Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeetham  Kochi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5153-3136","authenticated-orcid":false,"given":"Narayana","family":"Subramaniam","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Oncology Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeetham  Kochi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Missale","sequence":"additional","affiliation":[{"name":"IRCCS Ospedale Policlinico San Martino  Genoa Italy"},{"name":"Department of Otorhinolaryngology \u2013 Head and Neck Surgery University of Genova  Genoa Italy"},{"name":"Department of Molecular and Translational Medicine University of Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo","family":"Marchi","sequence":"additional","affiliation":[{"name":"IRCCS Ospedale Policlinico San Martino  Genoa Italy"},{"name":"Department of Plastic Surgery Chang Gung Memorial Hospital, Chang Gung University and Medical College  Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yogesh","family":"Dokhe","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Oncology Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeetham  Kochi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Smitha","family":"Vijayan","sequence":"additional","affiliation":[{"name":"Department of Pathology Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeetham  Kochi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajit","family":"Nambiar","sequence":"additional","affiliation":[{"name":"Department of Pathology Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeetham  Kochi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Mattavelli","sequence":"additional","affiliation":[{"name":"Unit of Otorhinolaryngology \u2013 Head and Neck Surgery, Department of Medical and Surgical Specialties Radiological Sciences and Public Health, University of Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Calza","sequence":"additional","affiliation":[{"name":"Unit of Biostatistics, Department of Molecular and Translational Medicine University of Brescia  Brescia Italy"},{"name":"Department of Medical Epidemiology and Biostatistics Karolinska Institute  Stockholm Sweden"},{"name":"Big &amp; Open Data Innovation Laboratory University of Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Bresciani","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Maxillofacial and Thyroid Surgery Fondazione IRCCS, National Cancer Institute of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesare","family":"Piazza","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Maxillofacial and Thyroid Surgery Fondazione IRCCS, National Cancer Institute of Milan  Milan Italy"},{"name":"Department of Oncology and Oncohematology University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piero","family":"Nicolai","sequence":"additional","affiliation":[{"name":"Section of Otorhinolaryngology \u2013 Head and Neck Surgery, Department of Neurosciences University of Padua  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Peretti","sequence":"additional","affiliation":[{"name":"IRCCS Ospedale Policlinico San Martino  Genoa Italy"},{"name":"Department of Otorhinolaryngology \u2013 Head and Neck Surgery University of Genova  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishnakumar","family":"Thankappan","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Oncology Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeetham  Kochi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subramania","family":"Iyer","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Oncology Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeetham  Kochi India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2015.12.017"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2000.tb00105.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23994"},{"key":"e_1_2_8_5_1","volume-title":"TNM classification of malignant tumours \u2013 8th edition","author":"Brierley JD","year":"2016"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2019.05.018"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdu125"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.56.6661"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdr118"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000000881"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-09-0948"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.1021"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000016206"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.7150\/jca.24530"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/00949655.2015.1016944"},{"key":"e_1_2_8_16_1","doi-asserted-by":"crossref","unstructured":"XiaoNhdnom: building nomograms for penalized Cox models with high\u2010dimensional survival data. 2016; 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