{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T18:55:39Z","timestamp":1779216939262,"version":"3.51.4"},"reference-count":62,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004329","name":"Javna Agencija za Raziskovalno Dejavnost RS","doi-asserted-by":"publisher","award":["P3\u20100083"],"award-info":[{"award-number":["P3\u20100083"]}],"id":[{"id":"10.13039\/501100004329","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The incidence and risk factors for the development of high\u2010grade dysplasia (HG\u2010D) and laryngeal squamous cell carcinoma (LSCC) were assessed in patients with laryngeal squamous cell papillomas (LSP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Clinical data, human papillomaviruses (HPV) typing, HPV E6\/E7 mRNA in situ hybridization, and sequencing of host genes in LSP biopsies of 163 patients were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Progression to HG\u2010D and LSCC was identified in 21.5% and 4.3% of LSP patients, respectively. A more advanced age at LSP onset and lack of HPV infection were detected as risk factors for the development of HG\u2010D and LSCC (<jats:italic>P<\/jats:italic> &lt;\u2009.05). The identification of HG\u2010D was associated with its progression to LSCC (<jats:italic>P<\/jats:italic> &lt;\u2009.05). Host gene mutations were identified in 3 of 7 patients with LSCC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The histological monitoring of LSP and HPV typing are necessary for early detection of epithelial changes. Further research is needed to elucidate the role of host gene mutations in LSCC transformation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.26560","type":"journal-article","created":{"date-parts":[[2020,12,2]],"date-time":"2020-12-02T05:32:45Z","timestamp":1606887165000},"page":"956-966","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Risk factors for the development of high\u2010grade dysplasia and carcinoma in patients with laryngeal squamous cell papillomas: Large retrospective cohort study"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0125-9650","authenticated-orcid":false,"given":"Da\u0161a","family":"Gluvaji\u0107","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology and Cervicofacial Surgery University Medical Centre  Ljubljana Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lea","family":"Ho\u0161njak","sequence":"additional","affiliation":[{"name":"Institute of Microbiology and Immunology, Faculty of Medicine University of Ljubljana  Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vida","family":"Stegel","sequence":"additional","affiliation":[{"name":"Department of Molecular Diagnostics Institute of Oncology  Ljubljana Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Srdjan","family":"Novakovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Molecular Diagnostics Institute of Oncology  Ljubljana Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8921-5109","authenticated-orcid":false,"given":"Nina","family":"Gale","sequence":"additional","affiliation":[{"name":"Institute of Pathology, Faculty of Medicine University of Ljubljana  Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Poljak","sequence":"additional","affiliation":[{"name":"Institute of Microbiology and Immunology, Faculty of Medicine University of Ljubljana  Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irena Ho\u010devar","family":"Bolte\u017ear","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Cervicofacial Surgery University Medical Centre  Ljubljana Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.44.1.393-400.1982"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-017-0788-z"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.5541040503"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2273.1986.tb02032.x"},{"key":"e_1_2_10_6_1","first-page":"93","volume-title":"WHO Classification of Head and Neck Tumours","author":"Richardson M","year":"2017"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.12565"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-007-0569-5"},{"issue":"1","key":"e_1_2_10_9_1","first-page":"51","article-title":"High incidence of high\u2010risk HPV in benign and malignant lesions of the larynx","volume":"39","author":"Duray A","year":"2011","journal-title":"Int J Oncol"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00874092"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200204000-00020"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2013.296"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)70471-1"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2016.08.002"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc798"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0463.2010.02618.x"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/0003489415608196"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/0003489414526848"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0099114"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2009.09.004"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00106-017-0378-0"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23808"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599814549730"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.22953"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599810391626"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940911800704"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20998"},{"key":"e_1_2_10_28_1","first-page":"615","article-title":"Spolno vedenje slovenskih srednje\u0161olcev v letu 2004","volume":"75","author":"Pinter B","year":"2006","journal-title":"Zdrav Vestn"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.23318"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2015.10.007"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0119154"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviromet.2008.07.014"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6890-5-10"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviromet.2008.09.002"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2014-306087"},{"issue":"4","key":"e_1_2_10_36_1","first-page":"65","article-title":"Development of a novel multiplex type\u2010specific quantitative real\u2010time PCR for detection and differentiation of infections with human papillomavirus types HPV2, HPV27, and HPV57","volume":"25","author":"Ho\u0161njak L","year":"2016","journal-title":"Acta Dermatovenerol Alp Pannonica Adriat"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djv403"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940311200402"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAP.0000000000000106"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.12427"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e318155a288"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1001\/archoto.2009.179"},{"key":"e_1_2_10_43_1","first-page":"1","article-title":"Tobacco smoke and involuntary smoking","volume":"83","author":"IARC Working Group on the Evaluation of Carcinogenic Risks to Humans","year":"2004","journal-title":"IARC Monogr Eval Carcinog Risks Hum"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2013.06.014"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-013-2358-7"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348949310200802"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21421"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199109000-00010"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016488909127491"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199805000-00021"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198710013171406"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880164"},{"issue":"2","key":"e_1_2_10_53_1","first-page":"133","article-title":"Metastatic squamous\u2010cell carcinoma of the lung arising in a 12\u2010year\u2010old boy with juvenile recurrent respiratory papillomatosis of neonatal onset","volume":"30","author":"Boudjemaa S","year":"2014","journal-title":"Turk Patoloji Derg"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2004.09.035"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.3109\/15513815.2014.968271"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.11691"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.1313"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djh183"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2009.08.018"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-07-1402"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2012.05.070"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0057207"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000147918.81733.49"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.26560","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hed.26560","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.26560","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T05:09:30Z","timestamp":1748840970000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.26560"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":62,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["10.1002\/hed.26560"],"URL":"https:\/\/doi.org\/10.1002\/hed.26560","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"2020-06-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}