{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T04:05:14Z","timestamp":1792555514435,"version":"4.5.0"},"reference-count":46,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,11,28]],"date-time":"2020-11-28T00:00:00Z","timestamp":1606521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The classic symptoms of Frey syndrome are gustatory sweating and flushing. Aims of the study were to describe prevalenceand severity of typical and atypical presentations of the disorder and to assess the effects of botulinum neurotoxin A (BoNT\u2010A) therapy in patients with Frey syndrome after parotidectomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this prospective, observational study on 18 patients, we assessed symptom severity before therapy, after 15\u2009days, 1, 3 and 6 months' follow\u2010up with the sweating\u2010flushing\u2010itch\u2010paresthesia\u2010pain (SFIPP) Frey scale specifically designed by the authors themselves for this study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Before BoNT\u2010A injection, all patients (100%) complained gustatory sweating, 80% paresthesia, 77% gustatory flushing, 60% pain and 60% gustatory itch. The SFIPP\u2010Frey overall score and the symptom\u2010specific ones decreased significantly at each post\u2010therapy control.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The prevalence of \u201cunusual\u201d manifestations is not negligible. BoNT\u2010A improves symptoms severity. The SFIPP\u2010Frey scale may be useful to assess symptoms and to monitor post\u2010therapy outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.26561","type":"journal-article","created":{"date-parts":[[2020,11,28]],"date-time":"2020-11-28T03:39:52Z","timestamp":1606534792000},"page":"949-955","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Not only gustatory sweating and flushing: Signs and symptoms associated to the Frey syndrome and the role of botulinum toxin A therapy"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0751-0882","authenticated-orcid":false,"given":"Maria Raffaella","family":"Marchese","sequence":"first","affiliation":[{"name":"Division of Otorhinolaryngology, Department of Aging, Neuroscience, Orthopedics and Head and Neck Sciences Fondazione Policlinico Universitario A. Gemelli IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Bussu","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology Azienda Ospedaliero Universitaria di Sassari  Sassari Italy"},{"name":"Division of Otolaryngology Universit\u00e0 di Sassari  Sassari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Settimi","sequence":"additional","affiliation":[{"name":"Division of Otorhinolaryngology, Department of Aging, Neuroscience, Orthopedics and Head and Neck Sciences Fondazione Policlinico Universitario A. Gemelli IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Scarano","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology Azienda Ospedaliera Pia Fondazione di Culto e Religione Cardinale G. 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