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These treatments may have detrimental effects on the oral microbiome, which is critical to maintaining physiological balance and health.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The effects of different OCC and OPC treatment types on the oral microbiome and metabolomic profiles for 24\u2010month post\u2010treatment in patients with OCC and OPC were investigated using 16S rRNA gene amplicon next\u2010generation sequencing and gas chromatography\u2013mass spectrometry (GC\u2013MS), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Chemoradiation resulted in oral dysbiosis with specific depletion of genera which regulate the enterosalivary nitrate\u2013nitrite\u2013nitric oxide pathway. These data also correlate with the oral metabolomic profiles with nitric oxide\u2010related precursor, modulator, or catalyst significantly downregulated in saliva samples from patients' postchemoradiation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Together, we have shown that oral dysbiosis due to the effects of chemoradiation could potentially have an impact on OCC and OPC patient's quality of life post\u2010treatment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.26619","type":"journal-article","created":{"date-parts":[[2021,2,4]],"date-time":"2021-02-04T08:00:23Z","timestamp":1612425623000},"page":"1521-1534","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Chemoradiation therapy changes oral microbiome and metabolomic profiles in patients with oral cavity cancer and oropharyngeal cancer"],"prefix":"10.1002","volume":"43","author":[{"given":"Yenkai","family":"Lim","sequence":"first","affiliation":[{"name":"The Saliva and Liquid Biopsy Translational Research Team, School of Biomedical Sciences, Institute of Health and Biomedical Innovation Queensland University of Technology  Brisbane Queensland Australia"},{"name":"The Translational Research Institute  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai Dun","family":"Tang","sequence":"additional","affiliation":[{"name":"The Saliva and Liquid Biopsy Translational Research Team, School of Biomedical Sciences, Institute of Health and Biomedical Innovation Queensland University of Technology  Brisbane Queensland Australia"},{"name":"The Translational Research Institute  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avinash V.","family":"Karpe","sequence":"additional","affiliation":[{"name":"The Land and Water, Commonwealth Scientific and Industrial Research Organisation Ecosciences Precinct Dutton Park  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Beale","sequence":"additional","affiliation":[{"name":"The Land and Water, Commonwealth Scientific and Industrial Research Organisation Ecosciences Precinct Dutton Park  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makrina","family":"Totsika","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences, Institute of Health and Biomedical Innovation Queensland University of Technology  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liz","family":"Kenny","sequence":"additional","affiliation":[{"name":"The School of Medicine University of Queensland, Royal Brisbane and Women's Hospital  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Morrison","sequence":"additional","affiliation":[{"name":"The University of Queensland Diamantina Institute, University of Queensland Translational Research Institute  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9039-8259","authenticated-orcid":false,"given":"Chamindie","family":"Punyadeera","sequence":"additional","affiliation":[{"name":"The Saliva and Liquid Biopsy Translational Research Team, School of Biomedical Sciences, Institute of Health and Biomedical Innovation Queensland University of Technology  Brisbane Queensland Australia"},{"name":"The Translational Research Institute  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,2]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"Oral cancer. 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