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We evaluated the risk of a second primary malignancy (SPM) in MiSGC patients and identified possible prognostic factors for survival using a large population database.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) data to evaluate the risk and prognosis of SPM in patients diagnosed with MiSGC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The risk of SPM increased in MiSGC patients compared with the endemic rate. The risk of SPM was slightly greater in female patients and who underwent radiotherapy. Age at primary diagnosis, sex, race, year of diagnosis, SEER stage, radiotherapy, SPM, histology, and tumor site were significant survival prognostic indicators of MiSGC patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Radiotherapy and female sex were risk factors for SPM after MiSGC. Long\u2010term surveillance for SPM was important in MiSGC patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.26641","type":"journal-article","created":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T18:05:46Z","timestamp":1613671546000},"page":"1769-1779","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Risk of second primary malignancy after minor salivary gland cancer: A Surveillance, Epidemiology, and End Results database analysis"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9781-7054","authenticated-orcid":false,"given":"Jingyi","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Eye, Ear, Nose, and Throat Hospital Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruoyan","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Eye, Ear, Nose, and Throat Hospital Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaole","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Eye, Ear, Nose, and Throat Hospital Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xicai","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Eye, Ear, Nose, and Throat Hospital Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Eye, Ear, Nose, and Throat Hospital Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Eye, Ear, Nose, and Throat Hospital Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Experimental Center, Eye, Ear, Nose, and Throat Hospital Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongmeng","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Eye, Ear, Nose, and Throat Hospital Fudan University  Shanghai China"},{"name":"Research Units of New Technologies of Endoscopic Surgery in Skull Base Tumor Chinese Academy of Medical Sciences  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0346-3193","authenticated-orcid":false,"given":"Dehui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Eye, Ear, Nose, and Throat Hospital Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,2,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1667\/RR0527.1"},{"key":"e_1_2_9_3_1","first-page":"1095","article-title":"Salivary gland cancer in the United States","volume":"8","author":"Sun EC","year":"1999","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2890080309"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S172725"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2012.10.002"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2009.10.004"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2015.02.096"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-015-3805-4"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2005.03.006"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2013.41"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.32208"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599811402899"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1983.57"},{"key":"e_1_2_9_15_1","unstructured":"World Health Organization. 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