{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:07:39Z","timestamp":1747148859332,"version":"3.40.5"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,2,26]],"date-time":"2021-02-26T00:00:00Z","timestamp":1614297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Matted nodes in human papillomavirus (HPV)\u2010mediated oropharyngeal squamous cell carcinoma (OPC) is an independent predictor of distant metastases and decreased overall survival. We aimed to classify imaging patterns of metastatic lymphadenopathy, analyze our classification system for reproducibility, and assess its prognostic value.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The metastatic lymphadenopathy was classified based on radiological characteristics for 216 patients with HPV\u2010mediated OPC. Patient outcomes were compared and inter\u2010rater reliability was calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The presence of \u22653 abutting lymph nodes with imaging features of surrounding extranodal extension (ENE), one subtype of matted nodes, was associated with worse 5\u2010year overall survival, overall recurrence\u2010free survival, regional recurrence\u2010free survival, and distant recurrence\u2010free survival (<jats:italic>p<\/jats:italic>\u2009\u2264\u20090.03). Other patterns were not significantly associated with outcome measures. Overall inter\u2010rater agreement was substantial (<jats:italic>\u03ba<\/jats:italic> = 0.73).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>One subtype of matted nodes defined by \u22653 abutting lymph nodes with imaging features of surrounding ENE is the radiological marker of worst prognosis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.26657","type":"journal-article","created":{"date-parts":[[2021,2,27]],"date-time":"2021-02-27T06:24:05Z","timestamp":1614407045000},"page":"1854-1863","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Novel imaging classification system of nodal disease in human papillomavirus\u2010mediated oropharyngeal squamous cell carcinoma prognostic of patient outcomes"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1311-099X","authenticated-orcid":false,"given":"Farahna","family":"Sabiq","sequence":"first","affiliation":[{"name":"Department of Radiology, Division of Neuroradiology University of Calgary  Calgary Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kitty","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Calgary  Calgary Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adarsh","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Radiology, Division of Neuroradiology University of Calgary  Calgary Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robyn","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Calgary  Calgary Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1091-3658","authenticated-orcid":false,"given":"Brock","family":"Debenham","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Alberta  Edmonton Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harold","family":"Lau","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Calgary  Calgary Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Skarsgard","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Calgary  Calgary Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guanmin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Community Health Sciences University of Calgary  Calgary Alberta 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