{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T07:47:55Z","timestamp":1781596075011,"version":"3.54.5"},"reference-count":12,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,2,19]],"date-time":"2021-02-19T00:00:00Z","timestamp":1613692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Middle ear adenomatous neuroendocrine tumors (MEANTs) are rare temporal bone tumors. This study evaluates its clinical behavior and therapy outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Retrospective case review in a tertiary referral center evaluating histopathology, immunohistochemistry, treatment, and outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nine patients were diagnosed with MEANT. One patient presented with locally invasive tumor and underwent extensive en\u2010bloc tumor resection with adjuvant radiotherapy. Seven of eight patients with locally non\u2010aggressive tumor confined to the tympanomastoid space underwent tumor resection. Two patients were disease\u2010free, five presented recurrence, even after apparent successful surgery. All tumors showed neuroendocrine features. Histopathology and immunohistochemistry did not yield prognostic tumor characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>MEANTs are rare tumors with uncertain biological behavior and subsequent unpredictable clinical course. The preferred treatment is complete surgical tumor resection. They have a high tendency for recurrence, irrespective of negative intermediary surgery. As of yet, there are no prognostic biomarkers, including histopathology and immunohistochemistry.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.26658","type":"journal-article","created":{"date-parts":[[2021,2,19]],"date-time":"2021-02-19T11:38:57Z","timestamp":1613734737000},"page":"1848-1853","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Neuroendocrine neoplasms of the middle ear: Unpredictable tumor behavior and tendency for recurrence"],"prefix":"10.1002","volume":"43","author":[{"given":"Rik J. L.","family":"van der Lans","sequence":"first","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery Amsterdam UMC, Vrije Universiteit Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle S. D.","family":"Engel","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery Amsterdam UMC, Vrije Universiteit Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes A.","family":"Rijken","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgical Oncology University Medical Center Utrecht Cancer Center  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik F.","family":"Hensen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0221-9538","authenticated-orcid":false,"given":"Elisabeth","family":"Bloemena","sequence":"additional","affiliation":[{"name":"Department of Pathology Amsterdam UMC, Vrije Universiteit Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marein","family":"van der Torn","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Dijklander Hospital  Hoorn The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles R.","family":"Leemans","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery Amsterdam UMC, Vrije Universiteit Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conrad F. 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