{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T12:53:48Z","timestamp":1778158428175,"version":"3.51.4"},"reference-count":39,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,3,9]],"date-time":"2021-03-09T00:00:00Z","timestamp":1615248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To assess the efficacy of intensity\u2010modulated radiation therapy (IMRT) for tumors of the nasal cavity and paranasal sinus (PNS) region.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Two hundred fourteen patients with tumors of the nasal cavity and PNS region treated with curative intent IMRT between 2007 and 2019 were included in this retrospective analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010one (24.1%) received definitive RT\/CTRT and 163 (75.9%) received adjuvant RT. Most common histology was squamous cell carcinoma (26.1%) followed by adenoid cystic carcinoma (21.5%). The median follow\u2010up was 43.5\u00a0months. The 5\u2010year local control (LC), event\u2010free survival (EFS), and overall survival (OS) for the entire cohort was 66.9%, 59%, and 73.9%, respectively. On univariate analysis treatment with nonsurgical modality, T classification and undifferentiated\/poorly differentiated histology were associated with inferior 5\u2010year LC, EFS, and OS. Four patients had late Grade 3\/Grade 4 ocular toxicity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>IMRT should be the standard of care for tumors of PNS region across all histologies and treatment setting.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.26669","type":"journal-article","created":{"date-parts":[[2021,3,9]],"date-time":"2021-03-09T11:19:33Z","timestamp":1615288773000},"page":"2045-2057","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Intensity\u2010modulated radiation therapy for nasal cavity and paranasal sinus tumors: Experience from a single institute"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0744-4838","authenticated-orcid":false,"given":"Sarbani Ghosh","family":"Laskar","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Tata Memorial Centre Homi Bhabha National Institute  Mumbai Maharashtra 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