{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T10:47:24Z","timestamp":1789469244284,"version":"build-2803163510"},"reference-count":74,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,3,9]],"date-time":"2021-03-09T00:00:00Z","timestamp":1615248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Head and neck surgery is a broad discipline that involves the management of complex conditions such as burns, skin cancer, head and neck cancer, congenital abnormalities, and facial rejuvenation. For patients with cancer, surgery, radiotherapy, and chemotherapy are often the main modes of treatment. Many patients require follow\u2010up reconstructive surgery, and the use of stem cells offers novel treatments that could aid recovery. Laryngeal, tracheal, and neuronal tissues are frequently damaged by surgery in the head and neck and these tissues have little intrinsic regenerative ability. Pluripotent embryonic stem cells retain the ability to differentiate into a wide variety of cells meaning that large tissue defects can be reduced by stimulating new cell growth. Research has demonstrated potential benefits of using stem cells in facial rejuvenation procedures and the management of burns sequelae. The advancements made in the use of adult progenitor stem cells as a possible source for pluripotent stem cells (induced pluripotent stem cells) mean that ethical considerations around the use of embryological tissue can be minimized, allowing for more research to take place. Currently, the evidence base for the use of stem cells in head and neck surgery is limited, but it has now been proven that stem cells can act as a source for lost or damaged tissue in the head and neck. With continuous advancements being made in the fields of tissue engineering, it is likely that stem cells will play a major role in head and neck surgery in the future.<\/jats:p>","DOI":"10.1002\/hed.26674","type":"journal-article","created":{"date-parts":[[2021,3,10]],"date-time":"2021-03-10T02:59:42Z","timestamp":1615345182000},"page":"1928-1938","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Update on the role of emerging stem cell technology in head and neck medicine"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8980-1792","authenticated-orcid":false,"given":"Harry","family":"Spencer","sequence":"first","affiliation":[{"name":"Department of Vascular Surgery St Georges Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navid","family":"Moshkbouymatin","sequence":"additional","affiliation":[{"name":"UK Territory Manager CELLINK  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2701-626X","authenticated-orcid":false,"given":"William Richard","family":"Webb","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Health and Social Sciences Canterbury Christ Church University  Chatham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil","family":"Joshi","sequence":"additional","affiliation":[{"name":"Department of Ear, Nose and Throat Surgery University Hospital Lewisham  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alwyn","family":"D'Souza","sequence":"additional","affiliation":[{"name":"Department of Ear, Nose and Throat Surgery University Hospital Lewisham  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/74447"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-60327-169-1_2"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.07.024"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2009.06.008"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.5966\/sctm.2016-0201"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/14653240600855905"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.15283\/ijsc.2014.7.2.118"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-018-1485-8"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20150025"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0001886"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2005-0342"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-9255-2-8"},{"issue":"7","key":"e_1_2_8_14_1","first-page":"1327","article-title":"Effects of human bone marrow mesenchymal stem cells on burn injury healing in a mouse model","volume":"6","author":"Xue L","year":"2013","journal-title":"Int J Clin Exp Pathol"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2014.01.023"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-3659(90)90129-H"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.21200"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100090504"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.2005.11.1198"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1369-7021(11)70058-X"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0142-9612(95)00351-7"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep23367"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s11658-016-0012-2"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2006.03.017"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-018-0850-0"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.05.041"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2008.04.023"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2019.00255"},{"key":"e_1_2_8_29_1","unstructured":"MoshkbouymatinN.Identification and characterisation of tracheal cartilage derived stem cells for airway tissue engineering. ethesis. 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