{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:45:43Z","timestamp":1786977943214,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,3,10]],"date-time":"2021-03-10T00:00:00Z","timestamp":1615334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Parathyroid carcinoma (PC) requires preoperative prediction for appropriate surgical management. Differentiation from symptomatic primary hyperparathyroidism (sPHPT) cohort is difficult.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Patients with sPHPT from a tertiary\u2010care center, Western India, including Cohort\u2010A (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u200919 [10\/M; 9\/F]) with PC and Cohort\u2010B (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u200993 [33\/M; 60\/F] with benign parathyroid lesions) were compared to derive predictors for differential diagnosis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There were no differences in clinical or biochemical parameters between the two cohorts. Comparison of CECT parameters showed that irregular shape, tumor heterogeneity, infiltration, short\/long\u2010axis ratio &gt;0.76, and long\u2010diameter &gt;30\u2009mm had high negative\u2010predictive value and intratumoral calcification had 100% positive\u2010predictive value to diagnose PC; whereas there were no differences in contrast\u2010enhancement patterns. Long diameter, short\/long\u2010axis ratio, and heterogeneity were significant predictors on multivariate analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>It is difficult to predict diagnosis of PC in an Indian sPHPT cohort based on clinical and biochemical parameters, whereas CECT parathyroid\u2010based parameters can aid in diagnosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.26677","type":"journal-article","created":{"date-parts":[[2021,3,10]],"date-time":"2021-03-10T03:02:55Z","timestamp":1615345375000},"page":"2069-2080","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Preoperative prediction of parathyroid carcinoma in an Asian Indian cohort"],"prefix":"10.1002","volume":"43","author":[{"given":"Ravikumar","family":"Shah","sequence":"first","affiliation":[{"name":"Department of Endocrinology Seth GS Medical College &amp; KEM Hospital  Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikrant","family":"Gosavi","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Seth GS Medical College &amp; KEM Hospital  Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhishek","family":"Mahajan","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis and Imaging Tata Memorial Center  Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sushil","family":"Sonawane","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Seth GS Medical College &amp; KEM Hospital  Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priya","family":"Hira","sequence":"additional","affiliation":[{"name":"Department of Radiology Seth GS Medical College &amp; KEM Hospital  Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vineeth","family":"Kurki","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis and Imaging Tata Memorial Center  Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Munita","family":"Bal","sequence":"additional","affiliation":[{"name":"Department of Pathology Tata Memorial Center  Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pragati","family":"Sathe","sequence":"additional","affiliation":[{"name":"Department of Pathology Seth GS Medical College &amp; 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