{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T23:53:50Z","timestamp":1790726030060,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,4,15]],"date-time":"2021-04-15T00:00:00Z","timestamp":1618444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>After head and neck cancer (HNC) treatment, dysgeusia may be a barrier to oral intake. In this exploratory study, we prospectively examined taste perception, clinician\u2010rated (CRO) and patient\u2010reported (PRO) taste changes and their effect on oral intake postradiotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010eight patients were assessed at baseline, treatment weeks 2 and 4, and 1, 3, and 6\u00a0months post\u2010treatment using a whole\u2010mouth taste test and associated CRO and subjective PRO measures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Greater taste impairment was reflected by subjective than by a whole\u2010mouth taste test. The most significant and consistent decline occurred mid\u2010treatment. The Chemotherapy\u2010Induced Taste Alteration Scale (PRO) discomfort subscale correlated significantly with maintaining an oral diet, percent of oral intake, and appetite level from mid\u2010treatment to 6\u00a0months post\u2010treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>PRO results indicated ongoing oral intake issues. Whole\u2010mouth taste tests may fail to fully reflect functional taste\u2010loss. Dysgeusia prevention and treatment methods are needed to improve patient outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.26690","type":"journal-article","created":{"date-parts":[[2021,4,16]],"date-time":"2021-04-16T01:52:46Z","timestamp":1618537966000},"page":"2159-2177","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Longitudinal comparisons of a whole\u2010mouth taste test to clinician\u2010rated and patient\u2010reported outcomes of dysgeusia postradiotherapy in patients with head and neck cancer and associations with oral intake"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9977-8685","authenticated-orcid":false,"given":"Barbara Pisano","family":"Messing","sequence":"first","affiliation":[{"name":"Greater Baltimore Medical Center, The Milton J Dance, Jr. Head and Neck Center, Head &amp; Neck Surgery, Johns Hopkins Voice Center at GBMC  Baltimore Maryland 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