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A systematic search identified studies which included patients receiving ventral skull base reconstruction in the setting of pre\u2010operative radiation. A meta\u2010analysis using a random effects model was conducted to estimate an odds ratio of cerebrospinal fluid (CSF) leak in patients exposed to pre\u2010operative radiation. A meta\u2010analysis of 13 studies demonstrated that the odds ratio of CSF leak was 1.73 (95% CI 0.98\u20133.05). The majority of studies (77%) used vascularized tissue grafts for reconstruction. We identified an increased incidence of CSF leak among patients undergoing ventral skull base reconstruction after prior radiation therapy, although not of statistical significance. Skull base surgeons should exercise caution when planning reconstruction in this population.<\/jats:p>","DOI":"10.1002\/hed.26709","type":"journal-article","created":{"date-parts":[[2021,5,11]],"date-time":"2021-05-11T16:41:59Z","timestamp":1620751319000},"page":"2795-2806","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The effect of prior radiation on the success of ventral skull base reconstruction: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7774-5786","authenticated-orcid":false,"given":"Michael","family":"Yong","sequence":"first","affiliation":[{"name":"Division of Otolaryngology \u2013 Head and Neck Surgery University of British Columbia Faculty of Medicine  Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu Qi","family":"Wu","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology \u2013 Head and Neck Surgery University of British Columbia Faculty of Medicine  Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3903-8204","authenticated-orcid":false,"given":"Shirley","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head &amp; Neck Surgery M. 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