{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T03:30:07Z","timestamp":1771299007068,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,4,28]],"date-time":"2021-04-28T00:00:00Z","timestamp":1619568000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81672386"],"award-info":[{"award-number":["81672386"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To evaluate the role of postoperative treatment in parotid gland carcinoma (PGC) based on risk stratification.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>A total of 301 PGC patients were retrospectively analyzed using risk stratification. The Kaplan\u2013Meier method and Cox analysis were performed to conduct survival analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the high\u2010risk group, those treated with postoperative radiotherapy (RT) had a better 5\u2010year disease\u2010free survival (DFS) than those treated with surgery alone. In the low\u2010risk group, both surgery\u2009+\u2009RT and surgery\u2009+ \u2009chemotherapy (CT) significantly improved DFS when compared with surgery alone. Cox analysis showed that patients who underwent surgery\u2009+\u2009RT or surgery + CT had a lower risk of disease progression than those who underwent surgery alone in the low\u2010risk group. In the high\u2010risk group, patients who underwent surgery\u2009+\u2009RT had a lower risk of disease progression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Postoperative RT showed considerable benefit in improving disease control in patients with PGC, even in those without high\u2010risk factors.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.26722","type":"journal-article","created":{"date-parts":[[2021,4,28]],"date-time":"2021-04-28T18:56:22Z","timestamp":1619636182000},"page":"2488-2496","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Survival outcomes in patients with parotid gland carcinoma treated with postoperative therapies using risk stratification"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8112-9508","authenticated-orcid":false,"given":"Zhi\u2010Gong","family":"Wei","sequence":"first","affiliation":[{"name":"Department of 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Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5315-5469","authenticated-orcid":false,"given":"Jing\u2010Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Biotherapy, Cancer Center, West China Hospital Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8224-3740","authenticated-orcid":false,"given":"Ling","family":"He","sequence":"additional","affiliation":[{"name":"Department of Biotherapy, Cancer Center, West China Hospital Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3918-7437","authenticated-orcid":false,"given":"Xiao\u2010Li","family":"Mu","sequence":"additional","affiliation":[{"name":"Department of Biotherapy, Cancer Center, West China Hospital Sichuan University  Chengdu 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