{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T17:35:59Z","timestamp":1790012159277,"version":"4.0.1"},"reference-count":26,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Parotid gland mucoepidermoid carcinoma (MEC) has published five\u2010year cancer\u2010specific survival (CSS) rates of 77%\u201397%, with variance related to grade.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients receiving primary surgery for parotid gland MEC from 1995 to 2014 at a tertiary medical center underwent clinical review, histopathologic review, and cytogenetic analysis. Survival outcomes were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 58 patients, T\/N\/M classification was as follows: T1 in 35 patients, T2 in 14, T4a in 9, N0 in 53, N1 in 2, N2b in 3. Histologic grade was low in 27, intermediate in 17, and high in 12 patients with 98% <jats:italic>MAML2<\/jats:italic> positivity. All patients underwent parotidectomy, and seven patients received adjuvant radiation therapy. CSS was 100% at 5\u2009years and 94.1% at 10 and 15\u2009years. Two patients experienced locoregional recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Treatment with adequate surgical resection and adjuvant radiation therapy for high\u2010grade or advanced\u2010stage tumors yields excellent survival, independent of clinical stage or pathologic grade.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.26735","type":"journal-article","created":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T07:56:15Z","timestamp":1619855775000},"page":"2663-2671","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Mucoepidermoid carcinoma of the parotid gland: <scp>Twenty\u2010year<\/scp> experience in treatment and outcomes"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4219-9196","authenticated-orcid":false,"given":"Stephen A.","family":"Chan","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2014Head 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