{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:07:54Z","timestamp":1747148874632,"version":"3.40.5"},"reference-count":33,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,5,21]],"date-time":"2021-05-21T00:00:00Z","timestamp":1621555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Regional metastasis of head and neck cutaneous squamous cell carcinoma (HNcSCC) can be seen in either parotid and\/or cervical lymph nodes. The aim of this study was to assess whether there was a difference in prognosis between parotid and cervical nodal metastases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with regional metastasis from HNcSCC were identified from an institutional database. Disease\u2010specific (DSS) and overall survival (OS) were calculated using the Kaplan\u2013Meier method and Cox proportional hazards models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Five hundred and thirty\u2010five patients were identified with median follow\u2010up of 26.4\u00a0months (3\u2013255\u2009months). Two hundred and thirty\u2010five patients had parotid metastasis, 96 patients had neck metastasis, and 204 patients had both. On multivariable analysis, any regional metastasis to the neck when compared to parotid alone conferred worse DSS (HR 1.8, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.007) and OS (HR 1.3, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.024).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Regional metastasis of HNcSCC to the neck confers worse outcomes compared to metastasis to the parotid alone.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.26744","type":"journal-article","created":{"date-parts":[[2021,5,21]],"date-time":"2021-05-21T13:58:37Z","timestamp":1621605517000},"page":"2705-2711","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The significance of regional metastasis location in head and neck cutaneous squamous cell carcinoma"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4200-1610","authenticated-orcid":false,"given":"Craig 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Cancer Institute Chris O'Brien Lifehouse  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sydney","family":"Ch'ng","sequence":"additional","affiliation":[{"name":"Sydney Head and Neck Cancer Institute Chris O'Brien Lifehouse  Sydney New South Wales Australia"},{"name":"Sydney Medical School, Faculty of Medicine and Health Sciences University of Sydney  Sydney New South Wales Australia"},{"name":"Royal Prince Alfred Institute of Academic Surgery Sydney Local Health District  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Elliott","sequence":"additional","affiliation":[{"name":"Sydney Head and Neck Cancer Institute Chris O'Brien Lifehouse  Sydney New South Wales Australia"},{"name":"Sydney Medical School, Faculty of Medicine and Health Sciences University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruta","family":"Gupta","sequence":"additional","affiliation":[{"name":"Sydney Head and Neck Cancer Institute Chris O'Brien Lifehouse  Sydney New South Wales Australia"},{"name":"Sydney Medical School, Faculty of Medicine and Health Sciences University of Sydney  Sydney New South Wales Australia"},{"name":"Department of Tissue Pathology and Diagnostic Oncology Royal Prince Alfred Hospital, NSW Health Pathology  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8958-736X","authenticated-orcid":false,"given":"Tsu\u2010Hui ( Hubert)","family":"Low","sequence":"additional","affiliation":[{"name":"Sydney Head and Neck Cancer Institute Chris O'Brien Lifehouse  Sydney New South Wales Australia"},{"name":"Sydney Medical School, Faculty of Medicine and Health Sciences University of Sydney  Sydney New South Wales 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