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The purpose of this study was to assess the validity of a rat model for investigating the effect of CRT on respiratory\u2010swallow coordination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Videofluoroscopic swallow study was performed on 10 Sprague\u2010Dawley rats 3\u00a0months post\u2010CRT (3\u00a0mg\/kg Cisplatin, 10 fractions of 4.5\u00a0Gy\/day radiotherapy to tongue base), and 10 na\u00efve controls. We examined the effect of CRT on swallow apnea duration, diaphragm movement, and bolus kinematics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>CRT rats had a significant increase in postswallow inhale (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.008), which was associated with significantly longer swallow apnea durations, lower diaphragm displacement at swallow onset, and faster pharyngoesophageal bolus speed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The rat CRT model is valid for the study of respiratory\u2010swallow coordination due to the consistency of findings in this study with those reported in clinical CRT studies in HNC.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.26782","type":"journal-article","created":{"date-parts":[[2021,6,23]],"date-time":"2021-06-23T08:23:39Z","timestamp":1624436619000},"page":"2954-2966","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["<scp>Respiratory\u2010swallow<\/scp> coordination in a rat model of chemoradiation"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1045-261X","authenticated-orcid":false,"given":"Linda M.","family":"Rowe","sequence":"first","affiliation":[{"name":"Department of Communication Sciences and Disorders University of Wisconsin\u2010Madison  Madison Wisconsin USA"},{"name":"Department of Surgery\u2010Otolaryngology University of Wisconsin\u2010Madison  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine P.","family":"Connor","sequence":"additional","affiliation":[{"name":"Department of Communication 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