{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:43:08Z","timestamp":1786977788033,"version":"build-2736575974"},"reference-count":42,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,6,24]],"date-time":"2021-06-24T00:00:00Z","timestamp":1624492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Management of hypopharynx cancer is often extrapolated from larynx cancer. This report analyses treatment patterns and survival limited to hypopharynx cancer using the National Cancer Database (NCDB).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>There are 9314 patients diagnosed with hypopharynx cancer between 2004 and 2016. The association between treatment modality and survival was analyzed using Kaplan\u2013Meier survival curves and multivariable Cox regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Five\u2010year overall survival ranged from 45% for stage I to 21% for stage IVB. Treatment modality did not influence survival in stage I\/II. For stage III\/IV, chemoradiation and surgery\u2009+\u2009adjuvant therapy were equivalent. Surgery yielded improved survival for T4 disease. Human papillomavirus (HPV)\u2010positive tumors were present in 21% and were associated with improved hazard ratio of death (0.60,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0&lt;0.0001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Survival is superior for T4 hypopharynx cancer managed with surgery, while treatment modality does not impact outcomes for other T\u2010stages. HPV\u2010positive tumors are associated with improved survival regardless of treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.26793","type":"journal-article","created":{"date-parts":[[2021,6,24]],"date-time":"2021-06-24T05:43:06Z","timestamp":1624513386000},"page":"3042-3052","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Prognostic significance of human papillomavirus status and treatment modality in hypopharyngeal cancer"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9460-0730","authenticated-orcid":false,"given":"Nina","family":"Burbure","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Fox Chase Cancer Center  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Handorf","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Fox Chase Cancer Center  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Ridge","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Fox Chase Cancer Center  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8691-0387","authenticated-orcid":false,"given":"Jessica","family":"Bauman","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Fox Chase Cancer Center  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8377-0905","authenticated-orcid":false,"given":"Jeffrey C.","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Fox Chase Cancer Center  Philadelphia Pennsylvania USA"},{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Lewis Katz School of Medicine at Temple 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