{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:08:00Z","timestamp":1747148880790,"version":"3.40.5"},"reference-count":19,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,7,20]],"date-time":"2021-07-20T00:00:00Z","timestamp":1626739200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["5T32DC000027\u201029"],"award-info":[{"award-number":["5T32DC000027\u201029"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Human papillomavirus (HPV)\u2010positive tonsil and base of tongue (BOT) cancers have been considered together. However, important differences may exist.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Demographic and tumor characteristics, and survival, were compared by oropharyngeal cancer subsite from 2004 to 2016 in the National Cancer Database (NCDB). Trends in tonsillectomy from the National Health and Nutrition Examination Survey (NHANES) 2011\u20132014 were examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>HPV\u2010positive BOT (<jats:italic>N<\/jats:italic>\u00a0=\u00a013\u2009081) were older than HPV\u2010positive tonsil patients (<jats:italic>N<\/jats:italic>\u00a0=\u00a016\u2009874; mean 61.5 vs. 58.4\u2009years, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and individuals 70+ years were significantly more likely to have BOT tumors compared with individuals &lt;50 (adjusted odd ratio [aOR]\u00a0=\u00a02.9, 95%\u00a0confidence interval\u00a0=\u00a02.6\u20133.2). BOT patients were also more likely to be white, male, and have advanced tumor classification. Among 7418 NHANES participants, tonsillectomy was associated with older age and white race.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There are epidemiologic and tumor\u2010related differences among HPV\u2010positive tonsil and BOT carcinomas. Demographic differences may be attributable to tonsillectomy trends.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.26804","type":"journal-article","created":{"date-parts":[[2021,7,20]],"date-time":"2021-07-20T12:35:12Z","timestamp":1626784512000},"page":"3076-3085","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Epidemiologic distinctions between base of tongue and tonsil oropharyngeal carcinomas"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0904-2931","authenticated-orcid":false,"given":"Melina J.","family":"Windon","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carole","family":"Fakhry","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Johns Hopkins University School of Medicine  Baltimore Maryland USA"},{"name":"Department of Epidemiology Johns Hopkins Bloomberg School of Public Health  Baltimore Maryland USA"},{"name":"Bloomberg~Kimmel Institute for Cancer Immunotherapy Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutions  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8281-0829","authenticated-orcid":false,"given":"Danielle N.","family":"Margalit","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Brigham and Women's Hospital  Boston Massachusetts USA"},{"name":"Head and Neck Oncology Program Dana\u2010Farber Cancer Institute  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanujit","family":"Dey","sequence":"additional","affiliation":[{"name":"Center for Surgery and Public Health, Department of Surgery Brigham and Women's Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleni M.","family":"Rettig","sequence":"additional","affiliation":[{"name":"Head and Neck Oncology Program Dana\u2010Farber Cancer Institute  Boston Massachusetts USA"},{"name":"Division of Otolaryngology Brigham and Women's Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,7,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6733a2"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djn011"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2020.104652"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0912217"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pvr.2017.05.002"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24964"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2015.3602"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-015-4560-x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-88441-7"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-40618-3"},{"key":"e_1_2_9_12_1","unstructured":"NHANES 2011\u20102012 2013\u20102014. U.S. Department of Health and Human Services Centers for Disease Control and Prevention. National Health and Nutrition Examination Survey Data Web Site.https:\/\/wwwn.cdc.gov\/nchs\/nhanes\/Default.aspx. Accessed May 1 2020."},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5876(93)90004-M"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348949009900305"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2015.08.006"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2016.63"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/lio2.342"},{"volume-title":"Essentials of Oral Histology and Embryology","year":"2014","author":"Chiego DJ","key":"e_1_2_9_18_1"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.13140"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40463-018-0302-y"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.26804","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hed.26804","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.26804","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T21:18:51Z","timestamp":1693343931000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.26804"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,20]]},"references-count":19,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["10.1002\/hed.26804"],"URL":"https:\/\/doi.org\/10.1002\/hed.26804","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"type":"print","value":"1043-3074"},{"type":"electronic","value":"1097-0347"}],"subject":[],"published":{"date-parts":[[2021,7,20]]},"assertion":[{"value":"2020-12-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}