{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:40:03Z","timestamp":1792190403645,"version":"4.4.0"},"reference-count":64,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,7,6]],"date-time":"2021-07-06T00:00:00Z","timestamp":1625529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["EMR\/2017\/002792"],"award-info":[{"award-number":["EMR\/2017\/002792"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Senescence is a common denominator in wound healing, fibrosis, and cancer. Although, senescence is transiently antifibrotic, when prolonged, promotes fibrosis and malignant transformation. Eligible studies indexed in MEDLINE, Embase and Web of Science were searched to understand the role of cellular senescence in the pathogenesis of oral submucous fibrosis (OSF) and its malignant transformation. The senescence\u2010associated secretory phenotype (SASP) components like IL\u20101, IL\u20106, and GRO\u2010\u03b1 induce double\u2010strand DNA breaks in keratinocytes and drive genetic instability. SASP derived from myofibroblasts induces epithelial\u2013mesenchymal transition in OSF and facilitates cancer progression. The use of senolytics has been shown to eliminate senescent cells from the areas of fibrosis, thereby preventing malignancy. Naturally occurring agents such as apigenin and kaempferol inhibit SASP. Mechanistic insight into the emerging role of senescence in the pathogenesis of OSF and modalities to inhibit senescence\u2010associated antiapoptotic pathways as a supplementary therapy to prevent malignant transformation of OSF is underlined.<\/jats:p>","DOI":"10.1002\/hed.26805","type":"journal-article","created":{"date-parts":[[2021,7,6]],"date-time":"2021-07-06T07:55:48Z","timestamp":1625558148000},"page":"3153-3164","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Emerging role of cellular senescence in the pathogenesis of oral submucous fibrosis and its malignant transformation"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9235-0176","authenticated-orcid":false,"given":"Mohit","family":"Sharma","sequence":"first","affiliation":[{"name":"Department of Oral Pathology Sudha Rustagi College of Dental Sciences and Research  Faridabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7873-0877","authenticated-orcid":false,"given":"Keith D.","family":"Hunter","sequence":"additional","affiliation":[{"name":"Academic Unit of Oral and Maxillofacial Medicine and Pathology School of Clinical Dentistry  University of Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6657-4547","authenticated-orcid":false,"given":"Felipe Paiva","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Surgery School of Dentistry, Universidade Federal de Minas Gerais  Belo Horizonte MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0088-4777","authenticated-orcid":false,"given":"Raghu","family":"Radhakrishnan","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, Manipal College of Dental Sciences, Manipal Manipal Academy of Higher Education  Manipal India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2174\/1574892813666180227103147"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12513"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12543"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-018-0712-x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.02.031"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12456"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2016.1143211"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973-029X.102474"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-019-0324-5"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2839"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12370"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0142134"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2070"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2014.102"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2013.382"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.2485\/jhtb.27.199"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2016.3145"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr501221g"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.20718"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature25167"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2014-0468OC"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2009-1195"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12674"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-11-3386"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11762"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2011.01043.x"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/6175804"},{"issue":"2","key":"e_1_2_7_29_1","first-page":"687","article-title":"Stromal\u2013epithelial lactate shuttle induced by tumorderived interleukin1beta promotes cell proliferation in oral squamous cell carcinoma","volume":"41","author":"Wu J","year":"2018","journal-title":"Int J Mol Med"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1159\/000440954"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1006\/cyto.1997.0342"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.3402\/pba.v5.27743"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3838"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2005.05.006"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12219"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm5040039"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29636"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12768"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0188847"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgw113"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.7150\/jca.20523"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/5642148"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.2174\/1574892810666150708110608"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)74423-8"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00848"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2017.04.001"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2017.07.003"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.101130"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2379"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-18-1062"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-05261-x"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2014.02.005"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40495-016-0051-4"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6602746"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2014.07.119"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2008.00649.x"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbf.1467"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellbi.2007.09.003"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2017.04.019"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2009.04.032"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41368-020-00090-5"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41368-020-00087-0"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2015.06.013"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI95149"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1667\/RR14784.1"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.26805","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hed.26805","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.26805","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T21:19:40Z","timestamp":1693343980000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.26805"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,6]]},"references-count":64,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["10.1002\/hed.26805"],"URL":"https:\/\/doi.org\/10.1002\/hed.26805","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,6]]},"assertion":[{"value":"2020-09-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}