{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T00:00:52Z","timestamp":1751846452703,"version":"3.40.5"},"reference-count":26,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T00:00:00Z","timestamp":1626825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["R01 DE028282\u201001","R01 DE028529\u201001"],"award-info":[{"award-number":["R01 DE028282\u201001","R01 DE028529\u201001"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Preclinical evidence suggests a link between the renin\u2010angiotensin system and oncogenesis. We aimed to explore the impact of angiotensin\u2010converting enzyme inhibitors (ACEi) and angiotensin II receptor blockers (ARB) in head and neck cancer (HNC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Over 5000 patients were identified from the Surveillance, Epidemiology, and End Results\u2010Medicare linked dataset and categorized according to ACEi and ARB and diagnoses of chronic kidney disease (CKD) or hypertension (HTN). Overall survival (OS) and cancer\u2010specific survival (CSS) were compared using Cox multivariable regression (MVA), expressed as hazard ratios (HR) with 95% confidence intervals (95%CI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No significant MVA associations for OS or CSS were found for ACEi. Compared to patients with CKD\/HTN taking ARB, those with CKD\/HTN not taking ARB experienced worse OS (HR 1.28, 95%CI 1.09\u20131.51, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.003) and CSS (HR 1.23, 95%CI 1.00\u20131.50, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.050).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>ARB usage is associated with improved OS and CSS among HNC patients with CKD or HTN.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.26809","type":"journal-article","created":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T11:44:20Z","timestamp":1626867860000},"page":"3255-3275","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Survival impact of a<scp>ngiotensin\u2010converting<\/scp> enzyme inhibitors and angiotensin <scp>II<\/scp> receptor antagonists in head and neck cancer"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1616-7046","authenticated-orcid":false,"given":"William A.","family":"Stokes","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Winship Cancer Institute Emory University School of Medicine  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Molina","sequence":"additional","affiliation":[{"name":"Department of Health Systems, Management, and Policy Colorado School of Public Health  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3667-566X","authenticated-orcid":false,"given":"Jessica D.","family":"McDermott","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, Department of Medicine University of Colorado Denver  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rustain L.","family":"Morgan","sequence":"additional","affiliation":[{"name":"Division of Nuclear Medicine, Department of Radiology University of Colorado Denver  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Bickett","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Colorado Denver  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kareem R.","family":"Fakhoury","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Colorado Denver  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6205-5969","authenticated-orcid":false,"given":"Arya","family":"Amini","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology City of Hope Cancer Center  Duarte California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sana D.","family":"Karam","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Colorado Denver  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,7,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21654"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.53.5633"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(19)30410-3"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/eos.12356"},{"issue":"4","key":"e_1_2_8_7_1","first-page":"1073","article-title":"The angiotensin\u2010I\u2010converting enzyme inhibitor perindopril suppresses tumor growth and angiogenesis: possible role of the vascular endothelial growth factor","volume":"7","author":"Yoshiji 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