{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:21:30Z","timestamp":1790680890952,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,8,7]],"date-time":"2021-08-07T00:00:00Z","timestamp":1628294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["IK2 BX004360"],"award-info":[{"award-number":["IK2 BX004360"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cutaneous squamous cell carcinoma of the head\/neck (CSCCHN) is common due to chronic sun exposure. As CSCCHN highly expresses EGFR, we prospectively studied postoperative concurrent cetuximab with radiotherapy for locally advanced CSCCHN (LA\u2010CSCCHN).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>Single\u2010institutional phase II trial of LA\u2010CSCCHN (NCT XXXX). Adjuvant radiation was given with concurrent cetuximab. Primary endpoint of 2\u2010year LRC and secondary objectives of 2\u2010year disease\u2010free survival (DFS) and 2\u2010year OS were assessed by Kaplan\u2013Meier analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty\u2010four patients ages 47\u201388 (median 71\u2009years) were treated from 2014 to 2017. Fourteen patients had T3\/4 disease, 5 had N1 disease, and 7 were N2\/3. At median follow\u2010up of 42\u2009months, median OS and DFS was not reached and 64\u2009months. Two\u2010year OS was 75%, 2\u2010year DFS was 70.8%. LRC was 91.1% at 2\u2009years. All grade 3 adverse events were related to skin toxicity (12.5% radiation\u2010related dermatitis, 16.7% cetuximab\u2010related rash).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>LRC compares favorably to historical data examining postoperative radiation alone but requires further investigation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.26835","type":"journal-article","created":{"date-parts":[[2021,8,7]],"date-time":"2021-08-07T05:02:59Z","timestamp":1628312579000},"page":"3408-3416","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Adjuvant radiation and cetuximab improves local control in head and neck cutaneous squamous cell carcinoma: Phase\n                    <scp>II<\/scp>\n                    study"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6576-420X","authenticated-orcid":false,"given":"Paul J.","family":"Kreinbrink","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology University of Cincinnati  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle L.","family":"Mierzwa","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brad","family":"Huth","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Cincinnati  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin P.","family":"Redmond","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Cincinnati  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trisha M.","family":"Wise\u2010Draper","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology University of Cincinnati  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith","family":"Casper","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junan","family":"Li","sequence":"additional","affiliation":[{"name":"The Ohio State University College of Pharmacy  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2499-3516","authenticated-orcid":false,"given":"Vinita","family":"Takiar","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Cincinnati  Cincinnati Ohio USA"},{"name":"Cincinnati VA Medical Center  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2015.1187"},{"key":"e_1_2_10_3_1","unstructured":"American Cancer Society.Cancer facts and figures 2020.https:\/\/www.cancer.org\/content\/dam\/cancer\u2010org\/research\/cancer\u2010facts\u2010and\u2010statistics\/annual\u2010cancer\u2010facts\u2010and\u2010figures\/2020\/cancer\u2010facts\u2010and\u2010figures\u20102020.pdf. 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