{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T14:35:26Z","timestamp":1793370926524,"version":"4.5.0"},"reference-count":43,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,8,18]],"date-time":"2021-08-18T00:00:00Z","timestamp":1629244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Surgical site infections (SSI) are common complications of free\u2010flap reconstruction for head and neck cancer defects. This study aimed to identify risk factors for SSI following a significant change in local antibiotic prophylaxis practice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective cohort study was conducted of 325 patients receiving free\u2010flap reconstruction for head and neck cancer defects at a tertiary hospital in Melbourne, Australia between 2013 and 2019. Charts were queried for recipient SSI (primary outcome), donor SSI, other infections, antibiotic use, hospital length of stay, and mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Risk factors for SSI included female sex, T\u2010classification, hardware insertion, clindamycin prophylaxis, and operative duration. There was a trend toward increased SSI with shorter \u226424\u2009h prophylaxis (OR: 0.43).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Antibiotic duration and type were associated with SSI. Complexity of surgery, T\u2010classification, hardware use, and operative duration were also independently associated with SSI. A prospective trial is indicated to elicit optimal prophylactic antibiotic duration.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.26837","type":"journal-article","created":{"date-parts":[[2021,8,19]],"date-time":"2021-08-19T05:30:47Z","timestamp":1629351047000},"page":"3417-3428","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Risk factors for surgical site infection in free\u2010flap reconstructive surgery for head and neck cancer: Retrospective Australian cohort study"],"prefix":"10.1002","volume":"43","author":[{"given":"Peter Francis","family":"Gearing","sequence":"first","affiliation":[{"name":"The Royal Melbourne Hospital The University of Melbourne  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John Frederick","family":"Daly","sequence":"additional","affiliation":[{"name":"The Royal Melbourne Hospital The University of Melbourne  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas Shi Jie","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Plastic &amp; Reconstructive Surgery The Royal Melbourne Hospital  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasha","family":"Singh","sequence":"additional","affiliation":[{"name":"The Royal Melbourne Hospital The University of Melbourne  Parkville Victoria Australia"},{"name":"Victorian Infectious Diseases Unit The Peter Doherty Institute for Infection and Immunity  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anand","family":"Ramakrishnan","sequence":"additional","affiliation":[{"name":"Department of Plastic &amp; Reconstructive Surgery The Royal Melbourne Hospital  Parkville Victoria Australia"},{"name":"Department of Surgery The Royal Melbourne Hospital, The University of Melbourne  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2016.5688"},{"key":"e_1_2_9_3_1","volume-title":"Head and neck cancers in Australia. 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