{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T14:28:33Z","timestamp":1761920913065,"version":"3.40.5"},"reference-count":17,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,8,12]],"date-time":"2021-08-12T00:00:00Z","timestamp":1628726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The purpose of this study is to evaluate practice patterns and outcomes between intensity\u2010modulated radiation therapy (IMRT) and 3D\u2010conformal radiation (3D\u2010CRT) in early stage glottic cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The linked Surveillance, Epidemiology, and End Results (SEER)\u2010Medicare database was used to identify and compare patient and disease profiles, mortality, and toxicity in patients with T1\u20102 larynx cancer undergoing definitive radiation (RT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1520 patients underwent definitive radiation with 3D\u2010CRT (<jats:italic>n<\/jats:italic>\u00a0=\u00a01309) or IMRT (<jats:italic>n<\/jats:italic>\u00a0=\u00a0211). Non\u2010white race, those with a Charlson Comorbidity Index \u22652, T2 disease, and those treated at community practices were more likely to undergo IMRT. Rates of IMRT increased from 2006 to 2015, while relative rates of 3D\u2010CRT decreased. Two\u2010year CSS was superior with 3D\u2010CRT (hazard ratio [HR], 0.38; 95% confidence interval [CI], 0.22\u20130.65; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). There was no difference in OS between 3D\u2010CRT and IMRT (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.119).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients receiving 3D\u2010CRT had improved CSS compared to IMRT with no difference in OS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.26841","type":"journal-article","created":{"date-parts":[[2021,8,12]],"date-time":"2021-08-12T10:37:49Z","timestamp":1628764669000},"page":"3393-3403","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Outcomes between i<scp>ntensity\u2010modulated<\/scp> radiation therapy versus <scp>3D<\/scp>\u2010conformal in early stage glottic cancer"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6205-5969","authenticated-orcid":false,"given":"Arya","family":"Amini","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology City of Hope Cancer Center  Duarte California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rustain","family":"Morgan","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Colorado School of Medicine  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth","family":"Meyer","sequence":"additional","affiliation":[{"name":"Department of Health Systems Management and Policy, Colorado Comprehensive Cancer Center University of Colorado  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kareem","family":"Fakhoury","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Colorado School of Medicine  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colton","family":"Ladbury","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology City of Hope Cancer Center  Duarte California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Bickett","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Colorado School of Medicine  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica D.","family":"McDermott","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology University of Colorado School of Medicine  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Stokes","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Emory University  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sana D.","family":"Karam","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Colorado School of Medicine  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,8,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.06.014"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13014-020-01666-5"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70290-4"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.07.1687"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.04.061"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2007.01.006"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-014-3157-6"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prro.2015.05.004"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.27873"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23967"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.56.5218"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24552"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.63.9898"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.26308"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/1748-717X-5-74"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.3857\/roj.2019.00283"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.3857\/roj.2019.00619"}],"container-title":["Head &amp; 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