{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T09:55:00Z","timestamp":1780394100348,"version":"3.54.1"},"reference-count":24,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,8,21]],"date-time":"2021-08-21T00:00:00Z","timestamp":1629504000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study aims to develop and validate a new classification system that better predicts combined risk of neurological and neurovascular complications following CBT surgery, crucial for treatment decision\u2010making.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Multinational retrospective cohort study with 199 consecutive cases. A cohort of 132 CBT cases was used to develop the new classification. To undertake external validation, assessment was made between the actual complication rate and predicted risk by the model on an independent cohort (<jats:italic>n<\/jats:italic>\u00a0=\u00a067).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Univariate analyses showed statistically significant associations between developing a complication and the following factors: craniocaudal dimension, volume, Shamblin classification, and Mehanna types. In the multivariate prognostic model, only Mehanna type remained as a significant risk predictor. The risk of developing complications increases with increasing Mehanna type.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We have developed and then validated a new classification and risk stratification system for CBTs, which demonstrated better prognostic power for the risk of developing neurovascular complications after surgery.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.26844","type":"journal-article","created":{"date-parts":[[2021,8,21]],"date-time":"2021-08-21T19:32:38Z","timestamp":1629574358000},"page":"3448-3458","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Development and validation of an improved classification and risk stratification system for carotid body tumors: Multinational collaborative cohort study"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5544-6224","authenticated-orcid":false,"given":"Hisham","family":"Mehanna","sequence":"first","affiliation":[{"name":"Institute for Head and Neck Studies and Education (InHANSE) University of Birmingham  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pankaj","family":"Mistry","sequence":"additional","affiliation":[{"name":"University of Warwick  Coventry UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawel","family":"Golusinski","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery, The Greater Poland Cancer Centre Poznan University of Medical Sciences  Poznan Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasquale","family":"Di Maio","sequence":"additional","affiliation":[{"name":"Section of Otolaryngology \u2013 Head and Neck Surgery University of Perugia  Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Nankivell","sequence":"additional","affiliation":[{"name":"Institute for Head and Neck Studies and Education (InHANSE) University of Birmingham  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Snider","sequence":"additional","affiliation":[{"name":"Vascular Surgery Unit, Department of Cardiovascular Sciences Policlinico Universitario A. Gemelli Foundation, Universit\u00e0 Cattolica del S. Cuore  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela M. R.","family":"Ferrante","sequence":"additional","affiliation":[{"name":"Vascular Surgery Unit, Department of Cardiovascular Sciences Policlinico Universitario A. Gemelli Foundation, Universit\u00e0 Cattolica del S. 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