{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:30:58Z","timestamp":1792099858818,"version":"4.4.0"},"reference-count":26,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T00:00:00Z","timestamp":1631664000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30CA016672"],"award-info":[{"award-number":["P30CA016672"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>High\u2010grade neuroendocrine carcinoma of the larynx (HG\u2010NECL) is rare and aggressive with limited data regarding response to systemic therapy. We evaluated clinicopathological features, therapeutic approaches, and outcomes in patients with laryngeal or hypopharyngeal HG\u2010NECL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data were retrospectively collected through 1997\u20132020. Median disease\u2010free (mDFS), progression\u2010free (mPFS), and overall survival (mOS) were estimated using the Kaplan\u2013Meier method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifteen patients were identified; most had locoregional (<jats:italic>N<\/jats:italic>\u00a0=\u00a07) or metastatic disease (<jats:italic>N<\/jats:italic>\u00a0=\u00a05). The main curative\u2010intent treatment was chemoradiation concurrent with platinum\u2010based chemotherapy; the rate of complete response was 78%. Most patients (80%) developed recurrence; the mDFS was 13.1\u00a0months. For the first\u2010line palliative therapy, the ORR and mPFS were 50% and 3.1\u00a0months, respectively. For all patients, the mOS was 17.8\u00a0months, and 8.6\u00a0months for metastatic disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Laryngeal HG\u2010NEC is associated with high relapse rates and dismal prognosis for those with recurrent\/metastatic disease. Novel therapeutic strategies are needed.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.26865","type":"journal-article","created":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T13:04:41Z","timestamp":1631711081000},"page":"3788-3795","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Therapeutic approaches and outcomes in patients with larynx or hypopharynx high\u2010grade neuroendocrine carcinoma: A s<scp>ingle\u2010center<\/scp> retrospective analysis"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3516-7105","authenticated-orcid":false,"given":"Luana Guimaraes","family":"Sousa","sequence":"first","affiliation":[{"name":"Department of Thoracic and Head and Neck Medical Oncology The University of Texas M. D. Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felippe","family":"Lazar Neto","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Head and Neck Medical Oncology The University of Texas M. D. Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danice Karagiannis","family":"Torman","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Head and Neck Medical Oncology The University of Texas M. D. Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo M.","family":"Diaz","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery The University of Texas M. D. Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David I.","family":"Rosenthal","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology The University of Texas M. D. Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bonnie S.","family":"Glisson","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Head and Neck Medical Oncology The University of Texas M. D. Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3531-8241","authenticated-orcid":false,"given":"Diana","family":"Bell","sequence":"additional","affiliation":[{"name":"Department of Pathology The University of Texas M. D. Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3561-215X","authenticated-orcid":false,"given":"Renata","family":"Ferrarotto","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Head and Neck Medical Oncology The University of Texas M. D. Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,15]]},"reference":[{"key":"e_1_2_10_2_1","volume-title":"WHO Classification of Tumours. 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