{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T01:07:20Z","timestamp":1788829640138,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,9,27]],"date-time":"2021-09-27T00:00:00Z","timestamp":1632700800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To evaluate the importance of larynx compartments in the prognosis of T3\u2010T4a laryngeal cancer treated with transoral laser microsurgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Two hundred and two consecutive pT3\u2010T4a larynx carcinomas. Pre\u2010epiglottic space involvement, anterior and posterior paraglottic space (PGS) involvement, vocal cord, and arytenoid mobility were determined. Local control with laser (LC), overall survival (OS), disease\u2010specific survival (DSS), and laryngectomy\u2010free survival (LFS) were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The lowest LC was found in tumors with fixed arytenoid. In the multivariate analysis, positive margins (hazard ratio [HR]\u00a0=\u00a00.289 [0.085\u20130.979]) and anterior (HR\u00a0=\u00a00.278 [0.128\u20130.605]) and posterior (HR\u00a0=\u00a00.269 [0.115\u20130.630]) PGS invasion were independent factors of a reduced LC. Anterior (HR\u00a0=\u00a03.613 [1.537\u20138.495]) and posterior (HR\u00a0=\u00a05.195 [2.167\u201312.455]) PGS involvement were independent factors of total laryngectomy. Five\u2010year OS, DSS, and LFS rates were 63.9%, 77.5%, and 77.5%, respectively. Patients with posterior PGS presented a reduced 5\u2010year LFS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Tumor classification according to laryngeal compartmentalization depicts strong correlation with LC and LFS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.26878","type":"journal-article","created":{"date-parts":[[2021,9,27]],"date-time":"2021-09-27T16:29:22Z","timestamp":1632760162000},"page":"3832-3842","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Transoral laser microsurgery in locally advanced laryngeal cancer: Prognostic impact of anterior versus posterior compartments"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4399-5522","authenticated-orcid":false,"given":"Isabel","family":"Vilaseca","sequence":"first","affiliation":[{"name":"Otorhinolaryngology Head Neck Surgery Department Hospital Cl\u00ednic  Barcelona Spain"},{"name":"School of Medicine, Department of Surgery and Medical\u2010Surgical Specialties Universitat de Barcelona  Barcelona Spain"},{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer, IDIBAPS  Barcelona Spain"},{"name":"Head Neck Cl\u00ednic Ag\u00e8ncia de Gesti\u00f3 d'Ajuts Universitaris i de Recerca  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesc Xavier","family":"Aviles\u2010Jurado","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Head Neck Surgery Department Hospital Cl\u00ednic  Barcelona Spain"},{"name":"School of Medicine, Department of Surgery and Medical\u2010Surgical Specialties Universitat 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Medical\u2010Surgical Specialties Universitat de Barcelona  Barcelona Spain"},{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer, IDIBAPS  Barcelona Spain"},{"name":"Radiology Department Hospital Cl\u00ednic  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Jos\u00e9","family":"Grau","sequence":"additional","affiliation":[{"name":"School of Medicine, Department of Surgery and Medical\u2010Surgical Specialties Universitat de Barcelona  Barcelona Spain"},{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer, IDIBAPS  Barcelona Spain"},{"name":"Head Neck Cl\u00ednic Ag\u00e8ncia de Gesti\u00f3 d'Ajuts Universitaris i de Recerca  Barcelona Spain"},{"name":"Medical Oncology Department Hospital Cl\u00ednic  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neus","family":"Baste","sequence":"additional","affiliation":[{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer, 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