{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T02:59:09Z","timestamp":1777949949443,"version":"3.51.4"},"reference-count":27,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,9,24]],"date-time":"2021-09-24T00:00:00Z","timestamp":1632441600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This exploratory, registry\u2010based, cross\u2010sectional study aimed to evaluate patients' health\u2010related quality of life (HRQOL) in a subsite of oropharyngeal cancer: cancer of the base of the tongue (CBT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>CBT patients, treated with curative intent, completed the EORTC QLQ\u2010C30 and QLQ\u2010H&amp;N35 questionnaires 15\u2009months after diagnosis. The HRQOL of CBT patients was compared to reference scores from the general population and to that of tonsillar carcinoma patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The 190 CBT patients scored significantly worse than members of the general population on most scales. CBT patients with human papilloma virus (HPV)\u2010positive tumors had significantly better HRQOL on 8 of 28 scales than HPV\u2010negative patients. Compared to 405 tonsillar carcinoma patients, CBT patients had significantly worse HRQOL on 8 of the 28 scales, the majority local head and neck related problems.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>One\u2009year after treatment, CBT patients' HRQOL was significantly worse in many areas compared to that of the general population and slightly worse than that of tonsillar carcinoma patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.26882","type":"journal-article","created":{"date-parts":[[2021,9,24]],"date-time":"2021-09-24T23:45:21Z","timestamp":1632527121000},"page":"3843-3856","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["A national study of health\u2010related quality of life in patients with cancer of the base of the tongue compared to the general population and to patients with tonsillar carcinoma"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9538-5254","authenticated-orcid":false,"given":"Malin","family":"Berg","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery, Institute of Clinical Sciences Sahlgrenska Academy at University of Gothenburg, Sahlgrenska University Hospital  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2925-0452","authenticated-orcid":false,"given":"Ali","family":"Adnan","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery, Institute of Clinical Sciences Sahlgrenska Academy at University of Gothenburg, Sahlgrenska University Hospital  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"H\u00f6gmo","sequence":"additional","affiliation":[{"name":"Department of Oto\u2010Rhino\u2010Laryngology, Head and Neck Surgery Karolinska University Hospital  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helena","family":"Sj\u00f6din","sequence":"additional","affiliation":[{"name":"Theme Cancer, HHLH Karolinska University Hospital  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Gebre\u2010Medhin","sequence":"additional","affiliation":[{"name":"Department of Oncology and Radiation Physics Sk\u00e5ne University Hospital, Lund University  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00f6ran","family":"Laurell","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, Section of Otorhinolaryngology and Head and Neck Surgery Uppsala University  Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan","family":"Reizenstein","sequence":"additional","affiliation":[{"name":"Department of Oncology \u00d6rebro University Hospital and \u00d6rebro University  \u00d6rebro Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lovisa","family":"Farnebo","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Anaesthetics, Operations and Specialty Surgery Center, Department of Biomedical and Clinical Sciences  Link\u00f6ping Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lena Spaak","family":"Norberg","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences\/ENT Ume\u00e5 University  Ume\u00e5 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isak","family":"Notstam","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences\/ENT Ume\u00e5 University  Ume\u00e5 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik","family":"Holmberg","sequence":"additional","affiliation":[{"name":"Regional Cancer Center Western Sweden Sahlgrenska University Hospital  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hedda Haugen","family":"Cange","sequence":"additional","affiliation":[{"name":"Department of Oncology, Institute of Clinical Sciences, Sahlgrenska Academy at the University of Gothenburg Sahlgrenska University Hospital  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1813-108X","authenticated-orcid":false,"given":"Eva","family":"Hammerlid","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery, Institute of Clinical Sciences Sahlgrenska Academy at University of Gothenburg, Sahlgrenska University Hospital  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Swedish Head and Neck Cancer Register 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