{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T20:34:25Z","timestamp":1772224465985,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,10,15]],"date-time":"2021-10-15T00:00:00Z","timestamp":1634256000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004809","name":"Financiadora de Estudos e Projetos","doi-asserted-by":"publisher","award":["BR 102013003316 2"],"award-info":[{"award-number":["BR 102013003316 2"]}],"id":[{"id":"10.13039\/501100004809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Oral mucositis (OM) is the significant complication of radio\/chemotherapy treatment. This study evaluated the safety and efficacy of a mucoadhesive phytomedication containing curcuminoids and <jats:italic>Bidens pilosa L<\/jats:italic>. (FITOPROT) in the prevention\/treatment of OM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty\u2010two patients were randomized into the group's intervention and placebo. Adverse effect assessment, OM grading, pain, and saliva collection were carried at the 1st, 15th, 21st, and final of radiotherapy (RT). Inflammatory salivary mediators were measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>FITOPROT decreased the severity of OM from the 15th to the final RT, while the placebo showed an increase in the severity (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Intervention group had a lower number of patients with ulcerated OM at the final RT (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Phytomedication prevented increases of IL\u20108 levels and reduced the salivary nitrite during RT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>FITOPROT does not promote adverse effects, it appears to be effective at reducing the severity of OM, and it controls the concentration of pro\u2010inflammatory mediators.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.26892","type":"journal-article","created":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T19:13:02Z","timestamp":1634757182000},"page":"3922-3934","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Safety and efficacy of a mucoadhesive phytomedication containing curcuminoids and <i>Bidens pilosa L<\/i>. extract in the prevention and treatment of radiochemotherapy\u2010induced oral mucositis: Triple\u2010blind, randomized, placebo\u2010controlled, clinical trial"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1306-747X","authenticated-orcid":false,"given":"Diego Ant\u00f4nio Costa","family":"Arantes","sequence":"first","affiliation":[{"name":"Department of Stomatology (Oral Pathology) Federal University of Goi\u00e1s  Goi\u00e2nia Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Artur Christian Garcia","family":"da Silva","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology and Cellular Toxicology Federal University of Goi\u00e1s  Goi\u00e2nia Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nilceana Maya Aires","family":"Freitas","sequence":"additional","affiliation":[{"name":"Division of Radiotherapy Ara\u00fajo Jorge Hospital  Goi\u00e2nia Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eliana Martins","family":"Lima","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmaceutical Technology 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