{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T15:14:40Z","timestamp":1791472480558,"version":"4.3.4"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,10,18]],"date-time":"2021-10-18T00:00:00Z","timestamp":1634515200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970907"],"award-info":[{"award-number":["81970907"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771046"],"award-info":[{"award-number":["81771046"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81270015"],"award-info":[{"award-number":["81270015"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["10DZ1951300"],"award-info":[{"award-number":["10DZ1951300"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study aimed to introduce a novel loop neurorrhaphy technique using an innervated vascularized iliac bone flap (VIBF) with vascularized ilioinguinal nerve (IIN) to reconstruct the inferior alveolar nerve (IAN) and preserve lower lip sensation simultaneously with mandibular reconstruction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study prospectively included patients who underwent mandibular reconstruction using VIBF from May 2018 to April 2020. Subjects were allocated into two groups: (1) Group I; innervated VIBF with loop neurorrhaphy (IIN doubly anastomosed with IAN and mental nerve), (2) Group II (control); conventional VIBF. Evaluation was done with operative time, intraoperative indocyanine green (ICG), lower lip sensory assessment (two\u2010point discrimination [TPD] test and current perception threshold [CPT]), and drooling.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twelve patients were included; 6 in each group, (7 males and 5 females), age ranging from 18 to 57\u2009years (average: 36.75\u2009years). In all cases, intraoperative perfusion of IIN was confirmed by ICG. Group I showed a statistically significant more flap harvesting time compared with group II (mean difference, 5.67\u2009min; <jats:italic>P<\/jats:italic>\u00a0=\u20090.0091). There was a significant difference in sensory recovery favoring group I (<jats:italic>P<\/jats:italic>\u00a0&lt;\u20090.05). The TPD results in group I showed an average of 9.8\u00a0\u00b1\u20096.9\u2009mm and 6.2\u00a0\u00b1\u20095.7\u2009mm on operated and non\u2010operated sides, while Group II showed a poor sensory recovery, and the TPD showed an average of 24.6\u00a0\u00b1\u20096.7\u2009mm and 8.4\u00a0\u00b1\u20092.3\u2009mm on operated and non\u2010operated sides. The CPT results showed a significant difference between both groups. In Group I, the extent of drooling was 3.16\u2009\u00b1\u20090.75, while in Group II, the score was 1.6\u00a0\u00b1\u20090.81, revealing a significant difference favoring Group I.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Concurrent mandibular reconstruction using VIBF and loop neurorrhaphy with vascularized IIN to reconstruct IAN successfully restore lower jaw form and preserve lip sensation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.26896","type":"journal-article","created":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T09:08:49Z","timestamp":1634807329000},"page":"46-58","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Novel loop neurorrhaphy technique to preserve lower lip sensate in mandibular reconstruction using an innervated vascularized iliac bone flap"],"prefix":"10.1002","volume":"44","author":[{"given":"Ahmed","family":"Abdelrehem","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery \u2013 Head &amp; Neck Oncology, Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine; College of Stomatology, Shanghai Jiao Tong University; National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology  Shanghai China"},{"name":"Department of Craniomaxillofacial and Plastic Surgery, Faculty of Dentistry Alexandria University  Alexandria Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingcun","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery \u2013 Head &amp; Neck Oncology, Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine; College of Stomatology, Shanghai Jiao Tong University; National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xudong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery \u2013 Head &amp; Neck Oncology, Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine; College of Stomatology, Shanghai Jiao Tong University; National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqian","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery \u2013 Head &amp; Neck Oncology, Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine; College of Stomatology, Shanghai Jiao Tong University; National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4372-0465","authenticated-orcid":false,"given":"Mubarak Ahmed","family":"Mashrah","sequence":"additional","affiliation":[{"name":"Key Laboratory of Oral Medicine, Guangzhou Institute of Oral Disease Stomatology Hospital of Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7044-6137","authenticated-orcid":false,"given":"Chengyao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery \u2013 Head &amp; Neck Oncology, Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine; College of Stomatology, Shanghai Jiao Tong University; National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology  Shanghai China"},{"name":"Department of Head and Neck Cancer Center Chongqing University Cancer Hospital, Chongqing Cancer Institute &amp; Chongqing Cancer Hospital  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery \u2013 Head &amp; Neck Oncology, Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine; College of Stomatology, Shanghai Jiao Tong University; National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery \u2013 Head &amp; Neck Oncology, Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine; College of Stomatology, Shanghai Jiao Tong University; National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4405-5065","authenticated-orcid":false,"given":"Lei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery \u2013 Head &amp; Neck Oncology, Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine; College of Stomatology, Shanghai Jiao Tong University; National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000637-197807000-00002"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/003655402_000028041"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2008.03.002"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1991.01870190045010"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-005-0504-y"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cxom.2006.05.004"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-198909000-00001"},{"key":"e_1_2_9_9_1","first-page":"47","article-title":"Reconstruction of the mandible with a vascularized iliac bone or osteocutaneous flap","volume":"34","author":"Harii K","year":"1991","journal-title":"Jpn J Plast Reconstr Surg"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1989.01860270081019"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-2391(00)90155-1"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1061-3315(18)30013-1"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2011.12.028"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2015.05.010"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24326"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000003263"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(15)00310-1"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1006869"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/SAP.0000000000000855"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0278-2391(95)90055-1"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24924"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2015.04.013"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200307000-00029"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0007-117X(70)80067-1"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0278-2391(84)90318-5"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2018.10.002"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000004237"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0266-4356(86)90005-7"},{"key":"e_1_2_9_29_1","first-page":"S2468","article-title":"Labiomental sensation after segmental mandibulectomy and inferior alveolar nerve preservation for osteoradionecrosis","volume":"20","author":"Drouet J","year":"2020","journal-title":"J Stomatol Oral Maxillofac Surg"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2013.02.002"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000637-198503000-00008"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-199205000-00024"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-199306000-00020"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0363-5023(92)90315-G"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1000100"},{"issue":"2","key":"e_1_2_9_36_1","first-page":"127","article-title":"Vascularized versus nonvascularized Island median nerve grafts in the facial nerve regeneration and functional recovery of rats for facial nerve reconstruction study","volume":"30","author":"Matsumine H","year":"2014","journal-title":"J Reconstr Microsurg"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0363-5023(85)80249-5"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000003060"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2013.07.018"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/ca.21098"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/micr.1920150406"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.26896","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hed.26896","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.26896","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T05:04:20Z","timestamp":1692507860000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.26896"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,18]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1002\/hed.26896"],"URL":"https:\/\/doi.org\/10.1002\/hed.26896","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,18]]},"assertion":[{"value":"2021-06-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}