{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T01:14:40Z","timestamp":1778980480517,"version":"3.51.4"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,11,11]],"date-time":"2021-11-11T00:00:00Z","timestamp":1636588800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["P50 DE026787"],"award-info":[{"award-number":["P50 DE026787"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To define the location of the initial contralateral lymph node (LN) metastasis in patients with oropharynx cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The location of the LN centroids from patients with oropharynx cancer and a single radiographically positive contralateral LN was defined. A clinical target volume (CTV) inclusive of all LN centroids was created, and its impact on dose to organs at risk was assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 55 patients of which 49\/55 had a single contralateral LN in level IIA, 4\/55 in level III, 1\/55 in level IIB, and 1\/55 in the retropharynx. Mean radiation dose to the contralateral parotid gland was 15.1 and 21.0\u00a0Gy, (<jats:italic>p<\/jats:italic> &lt;0.001) using the modeled high\u2010risk elective CTV and a consensus CTV, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We present a systematic approach for identifying the contralateral nodal regions at highest risk of harboring subclinical disease in patients with oropharynx cancer that warrants prospective clinical study.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.26924","type":"journal-article","created":{"date-parts":[[2021,11,11]],"date-time":"2021-11-11T10:09:24Z","timestamp":1636625364000},"page":"317-324","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Defining <scp>high\u2010risk<\/scp> elective contralateral neck radiation volumes for oropharynx cancer"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0570-3293","authenticated-orcid":false,"given":"Matthew E.","family":"Witek","sequence":"first","affiliation":[{"name":"Department of Human Oncology University of Wisconsin School of Medicine and Public Health, Carbone Cancer Center  Madison Wisconsin USA"},{"name":"Department of Radiation Oncology University of Maryland, School of Medicine  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4507-6167","authenticated-orcid":false,"given":"Neil M.","family":"Woody","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Taussig Cancer Institute, Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hima B.","family":"Musunuru","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, UPMC Hillman Cancer Center University of Pittsburgh, School of Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick M.","family":"Hill","sequence":"additional","affiliation":[{"name":"Department of Human Oncology University of Wisconsin School of Medicine and Public Health, Carbone Cancer Center  Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Poonam","family":"Yadav","sequence":"additional","affiliation":[{"name":"Department of Human Oncology University of Wisconsin School of Medicine and Public Health, Carbone Cancer Center  Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam R.","family":"Burr","sequence":"additional","affiliation":[{"name":"Department of Human Oncology University of Wisconsin School of Medicine and Public Health, Carbone Cancer Center  Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huaising 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