{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T02:10:51Z","timestamp":1782871851123,"version":"3.54.5"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,11,19]],"date-time":"2021-11-19T00:00:00Z","timestamp":1637280000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004622","name":"KWF Kankerbestrijding","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004622","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Neurocognition and speech, relevant domains in head and neck cancer (HNC), may be affected pretreatment. However, the prevalence of pretreatment deficits and their possible concurrent predictors are poorly understood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using an HNC prospective cohort (Netherlands Quality of Life and Biomedical Cohort Study, <jats:italic>N<\/jats:italic>\u2009\u2265\u2009444) with a cross\u2010sectional design, we investigated the estimated prevalence of pretreatment deficits and their relationship with selected demographic, behavioral, and disease\u2010related factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Using objective assessments, rates of moderate\u2010to\u2010severe neurocognitive deficit ranged between 4% and 8%. From patient\u2010reported outcomes, 6.5% of patients reported high levels of cognitive failures and 46.1% reported speech deficits. Patient\u2010reported speech functioning was worse in larynx compared to other subsites. Other nonspeech outcomes were unrelated to any variable. Patient\u2010reported neurocognitive and speech functioning were modestly correlated, especially in the larynx group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These findings indicate that a subgroup of patients with HNC shows pretreatment deficits, possibly accentuated in the case of larynx tumors.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.26930","type":"journal-article","created":{"date-parts":[[2021,11,20]],"date-time":"2021-11-20T06:36:00Z","timestamp":1637390160000},"page":"332-344","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Prevalence of neurocognitive and perceived speech deficits in patients with head and neck cancer before treatment: Associations with demographic, behavioral, and disease\u2010related factors"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4860-5952","authenticated-orcid":false,"given":"Vit\u00f3ria","family":"Piai","sequence":"first","affiliation":[{"name":"Department of Medical Psychology, Donders Centre for Medical Neuroscience Radboud University Medical Center  Nijmegen the Netherlands"},{"name":"Donders Institute for Brain, Cognition and Behaviour, Centre for Cognition Radboud University  Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Femke","family":"Jansen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery, Cancer Center Amsterdam UMC  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristoffer","family":"Dahlsl\u00e4tt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4507-4607","authenticated-orcid":false,"given":"Irma M.","family":"Verdonck\u2010de Leeuw","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery, Cancer Center Amsterdam UMC  Amsterdam the Netherlands"},{"name":"Department of Clinical, Neuro\u2010 and Developmental Psychology, Amsterdam Public Health Research Institute Vrije Universiteit  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Prins","sequence":"additional","affiliation":[{"name":"Department of Medical Psychology, Radboud Institute for Health Sciences Radboud University Medical Center  Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9","family":"Leemans","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery, Cancer Center Amsterdam UMC  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris H. J.","family":"Terhaard","sequence":"additional","affiliation":[{"name":"Department of Clinical, Neuro\u2010 and Developmental Psychology, Amsterdam Public Health Research Institute Vrije Universiteit  Amsterdam the Netherlands"},{"name":"Department of Radiotherapy University Medical Center  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes A.","family":"Langendijk","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, University Medical Centre Groningen University of Groningen  Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Baatenburg de Jong","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery Erasmus Cancer Institute, Erasmus MC  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes H.","family":"Smit","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Amsterdam Public Health, Amsterdam UMC Vrije Universiteit Amsterdam  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4784-0499","authenticated-orcid":false,"given":"Robert","family":"Takes","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Radboud Institute for Health Sciences Radboud University Medical Center  Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy","family":"P. 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