{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T22:15:01Z","timestamp":1766268901330,"version":"3.40.5"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T00:00:00Z","timestamp":1640217600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Study objectives were to determine whether the addition of postoperative radiation (PORT) resulted in a decline in oral function relative to surgery alone and to describe the longitudinal course of oral function following treatment of advanced oral cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a 36\u2010month retrospectively analyzed observational cohort study of patients with stage III\u2010IV oral cancer. Prospectively collected, oral functional outcomes were acquired pretreatment and 3, 6, 12, 24, and 36\u2009months post\u2010treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred and eighteen patients were included. Forty\u2010three patients treated with surgery alone were compared to 75 who received surgery with PORT. Mixed model analysis demonstrated the acute effect of PORT was associated with patient\u2010rated xerostomia (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and the late or persistent effect was associated with decreased clinician\u2010rated eating in public (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.008), understandability of speech (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.02), and normalcy of diet (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.005) compared with surgery alone. There were no differences between surgery alone and PORT groups in clinician\u2010rated feeding tube dependence or patient\u2010rated speech handicap.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The use of PORT was associated with a demonstrable decline in oral function in four of six outcomes measures relative to surgery alone.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.26968","type":"journal-article","created":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T21:52:01Z","timestamp":1640296321000},"page":"710-721","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Selected functional outcomes in advanced oral cancer: Comparison of surgery alone versus surgery with postoperative radiotherapy"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4953-050X","authenticated-orcid":false,"given":"Ciaran","family":"Lane","sequence":"first","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery, Max Rady College of Medicine University of Manitoba  Winnipeg Manitoba Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Candace","family":"Myers","sequence":"additional","affiliation":[{"name":"Section of Communication Disorders CancerCare Manitoba  Winnipeg Manitoba Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deping","family":"Jiang","sequence":"additional","affiliation":[{"name":"George &amp; Fay Yee Center for Healthcare Innovation University of Manitoba  Winnipeg Manitoba Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Cooke","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Max Rady College of Medicine University of Manitoba  Winnipeg Manitoba Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Kerr","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery, Max Rady College of Medicine University of Manitoba  Winnipeg Manitoba Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,12,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20279"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0708681"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.27224"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23387"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.1221"},{"volume-title":"Committee on Improving the Quality of Cancer Care: Addressing the Challenges of an Aging Population; 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