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Multivariate analyses with the Cox proportional hazards model were used to identify tumor\u2010related factors of in\u2010field failure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1039 patients with NPC received IMRT from 2012 to 2019 and 75 developed recurrences, with 88.0% (66\/75) considered as having in\u2010field failures. Multivariate analysis showed that pretreatment gross tumor volume of nasopharynx \u226568.8\u00a0mL and histopathological type of nonkeratinizing differentiated carcinoma (NKDC) were the independent tumor factors of in\u2010field local failure, while gross tumor volume of involved lymph nodes \u226519.9\u00a0mL and cervical nodal necrosis (CNN) were associated with in\u2010field regional failure (all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In\u2010field failure was the major pattern of recurrence in patients with NPC. Large tumor volume, NKDC, and CNN were the tumor factors associated with in\u2010field failure.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.26983","type":"journal-article","created":{"date-parts":[[2022,1,24]],"date-time":"2022-01-24T09:08:59Z","timestamp":1643015339000},"page":"876-888","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Tumor factors associated with in\u2010field failure for nasopharyngeal carcinoma after intensity\u2010modulated radiotherapy"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4440-5328","authenticated-orcid":false,"given":"Xixi","family":"Liu","sequence":"first","affiliation":[{"name":"Cancer Center, Union Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bian","family":"Wu","sequence":"additional","affiliation":[{"name":"Cancer Center, Union 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