{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T16:14:31Z","timestamp":1762272871529,"version":"3.40.5"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T00:00:00Z","timestamp":1644364800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2019R1F1A1040583","NRF\u20102020M2D9A1093990"],"award-info":[{"award-number":["2019R1F1A1040583","NRF\u20102020M2D9A1093990"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To evaluate the efficacy and safety of reducing target volume in definitive radiotherapy for HPV\u2010associated tonsil cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A single\u2010institution cohort of 90 patients with human papillomavirus (HPV)\u2010associated tonsil cancer who received definitive radiotherapy with a 5\u2010mm expansion from the gross tumor volume to clinical target volume between 2008 and 2019 were included. The overlapping volume of initial planning target volume and the recurrent tumor was calculated and categorized as one of three failure types: in\u2010field: \u226595%; marginal\u2010field: 50%\u201394%; and out\u2010field: &lt;50%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>With a median follow\u2010up of 59.4\u00a0months, the 3\u2010year and 5\u2010year local control rates were 94.4% and 92.8%, respectively. A total of seven local failures were identified, of which 4 (4.4%) were in\u2010field, 2 (2.2%) were marginal\u2010field, and 1 (1.1%) was out\u2010field. Grade 3 acute and late toxicities developed in 30 (33.3%) and 5 (5.6%) patients, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Reducing target volume could be an alternative option for selected patients with HPV\u2010associated tonsil cancer.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.26994","type":"journal-article","created":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T11:30:51Z","timestamp":1644406251000},"page":"989-997","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Reducing target volume in definitive radiotherapy for human papillomavirus\u2010associated tonsil cancer"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0839-4086","authenticated-orcid":false,"given":"Hye In","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Seoul National University Hospital, Seoul National University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin Ho","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Seoul National University Hospital, Seoul National University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joo Ho","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Seoul National University Hospital, Seoul National University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0167-7991","authenticated-orcid":false,"given":"Hong\u2010Gyun","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Seoul National University Hospital, Seoul National University College of Medicine  Seoul South Korea"},{"name":"Cancer Research Institute Seoul National University College of Medicine  Seoul South Korea"},{"name":"Institute of Radiation Medicine, Medical Research Center Seoul National University  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,2,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0912217"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.29.2904"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.00463"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32779-X"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32752-1"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.01007"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.03128"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.68.3300"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2019.11.021"},{"key":"e_1_2_6_11_1","unstructured":"NCCN.Clinical Practice Guidelines in Oncology. 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