{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T04:43:58Z","timestamp":1791434638713,"version":"4.3.3"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,3,4]],"date-time":"2022-03-04T00:00:00Z","timestamp":1646352000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Submandibular gland (SMG) transfer decreased radiation\u2010associated xerostomia in the 2\/3\u2010dimensional radiotherapy era. We evaluated the dosimetric implications of SMG transfer on modern intensity modulated radiotherapy (IMRT) plans.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eighteen oropharynx cancer patients underwent SMG transfer followed by IMRT; reoptimized plans using the baseline SMG location were generated. Mean salivary gland, oral cavity, and larynx doses were compared between clinical plans and reoptimized plans.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No statistically significant difference in mean SMG dose (27.53\u2009Gy vs. 29.61\u2009Gy) or total salivary gland dose (26.12\u2009Gy vs. 26.41\u2009Gy) was observed with or without SMG transfer (all <jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). Mean oral cavity and larynx doses were not statistically different. Neither tumor site, target volume crossing midline, stage, nor salivary gland volumes were associated with mean doses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Salivary gland doses were similar with or without SMG transfer. IMRT likely decreases the benefit of SMG transfer on the risk of radiation\u2010associated xerostomia.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.27021","type":"journal-article","created":{"date-parts":[[2022,3,4]],"date-time":"2022-03-04T09:36:39Z","timestamp":1646386599000},"page":"1213-1222","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Submandibular gland transfer for the prevention of radiation\u2010induced xerostomia in oropharyngeal cancer: Dosimetric impact in the intensity modulated radiotherapy era"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0416-8612","authenticated-orcid":false,"given":"Tugce","family":"Kutuk","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Miami Cancer Institute, Baptist Health South Florida  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole 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Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghan B.","family":"Crawley","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology Miami Cancer Institute, Baptist Health South Florida  Miami Florida USA"},{"name":"Herbert Wertheim College of Medicine Florida International University  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme","family":"Rabinowits","sequence":"additional","affiliation":[{"name":"Herbert Wertheim College of Medicine Florida International University  Miami Florida USA"},{"name":"Department of Hematology\/Oncology Miami Cancer Institute, Baptist Health South Florida  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adeel","family":"Kaiser","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Miami Cancer Institute, Baptist Health South Florida  Miami Florida USA"},{"name":"Herbert Wertheim College of 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