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Here we summarize the emerging histopathological markers showing powerful prognostic value, but are not included in pathology reports. Using PubMed, Scopus, Ovid Medline, and Web of Science databases, a systematic literature search was preformed to identify early OTSCC studies that investigated the prognostic significance of hematoxylin\u2013eosin\u2010based histopathologic markers. Our meta\u2010analysis showed that tumor budding was associated with overall survival (hazard ratio [HR] 2.32; 95% CI 1.40\u20133.84; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) and disease\u2010specific survival (DSS) (1.89; 95% CI 1.13\u20133.15; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.02). Worst pattern of invasion was associated with disease\u2010free survival (DFS) (1.95; 95% CI 1.04\u20133.64; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.04). Tumor\u2013stroma ratio was also associated with DFS (1.75, 95% CI 1.24\u20132.48; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) and DSS (1.69; 95% CI 1.19\u20132.42; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). Tumor budding, worst pattern of invasion, and tumor\u2013stroma ratio have a promising prognostic value in early OTSCC. The evaluation and reporting of these markers is cost\u2010effective and can be incorporated in daily practice.<\/jats:p>","DOI":"10.1002\/hed.27022","type":"journal-article","created":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T06:52:13Z","timestamp":1646117533000},"page":"1481-1491","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Emerging histopathologic markers in early\u2010stage oral tongue cancer: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1009-1375","authenticated-orcid":false,"given":"Amr","family":"Elseragy","sequence":"first","affiliation":[{"name":"Cancer and Translational Medicine Research Unit, Medical Research Center Oulu University of Oulu and Oulu University Hospital  Oulu Finland"},{"name":"Department of Oral and Maxillofacial Diseases University of Helsinki  Helsinki Finland"},{"name":"Department of Pathology University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2085-3185","authenticated-orcid":false,"given":"Ibrahim O.","family":"Bello","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Helsinki  Helsinki Finland"},{"name":"Department of Oral Medicine and Diagnostic Sciences King Saud University College of Dentistry  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Awais","family":"Wahab","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Diseases University of Helsinki  Helsinki Finland"},{"name":"Department of Pathology University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo D.","family":"Coletta","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnosis School of Dentistry, University of Campinas  Piracicaba S\u00e3o Paulo Brazil"},{"name":"Graduate Program in Oral Biology School of Dentistry, University of Campinas  Piracicaba S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0451-2404","authenticated-orcid":false,"given":"Antti A.","family":"M\u00e4kitie","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology \u2013 Head and Neck Surgery University of Helsinki and HUS Helsinki University Hospital  Helsinki Finland"},{"name":"Division of Ear, Nose and Throat Diseases, Department of Clinical Sciences, Intervention and Technology Karolinska Institutet and Karolinska University Hospital  Stockholm Sweden"},{"name":"Research Program in Systems Oncology, Faculty of Medicine University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilmo","family":"Leivo","sequence":"additional","affiliation":[{"name":"Institute of Biomedicine, Pathology University of Turku  Turku Finland"},{"name":"Turku University Central Hospital  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4106-314X","authenticated-orcid":false,"given":"Alhadi","family":"Almangush","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Helsinki  Helsinki Finland"},{"name":"Research Program in Systems Oncology, Faculty of Medicine University of Helsinki  Helsinki Finland"},{"name":"Institute of Biomedicine, Pathology University of Turku  Turku Finland"},{"name":"Faculty of Dentistry Misurata University  Misurata Libya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuula","family":"Salo","sequence":"additional","affiliation":[{"name":"Cancer and Translational Medicine Research Unit, Medical Research Center Oulu University of Oulu and Oulu University Hospital  Oulu Finland"},{"name":"Department of Oral and Maxillofacial Diseases University of Helsinki  Helsinki Finland"},{"name":"Department of Pathology University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2010.06.006"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-020-02930-5"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2014.2103"},{"key":"e_1_2_7_5_1","volume-title":"TNM Classification of Malignant Tumours","author":"Brierley 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