{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T06:35:01Z","timestamp":1771569301558,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T00:00:00Z","timestamp":1648684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Associations between patient\u2010reported outcomes and dose to organs at risk (OARs) may promote management and guide future investigations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively evaluated PROs and OAR dose in head and neck (H&amp;N) cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In 169 patients, we identified weak associations between: \u201cDifficulty swallowing\/chewing\u201d and increased mean RT dose to the oral cavity, larynx, pharyngeal constrictor muscles (PCM) and contralateral parotid; \u201cchoking\/coughing\u201d and larynx mean dose; \u201cproblems with mucus in mouth and throat\u201d and oral cavity, contralateral parotid mean dose and parotid V30, contralateral submandibular gland and PCM mean dose; \u201cdifficulty with voice\/speech\u201d and oral cavity, contralateral parotid, contralateral submandibular gland and larynx mean dose; and \u201cdry mouth\u201d and ipsilateral submandibular gland, oral cavity and PCM mean dose.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We identified weak associations between PRO and dose to OARs\u2014these data can guide on treatment management, patient counseling, and serve as a baseline for future investigations.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.27031","type":"journal-article","created":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T07:47:36Z","timestamp":1648712856000},"page":"1442-1452","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Association between radiation dose to organs at risk and acute patient reported outcome during radiation treatment for head and neck cancers"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5770-4768","authenticated-orcid":false,"given":"Mona","family":"Arbab","sequence":"first","affiliation":[{"name":"Brigham and Women's Hospital  Boston Massachusetts USA"},{"name":"Department of Radiation Oncology Indiana University  Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010Hui","family":"Chen","sequence":"additional","affiliation":[{"name":"Dana\u2010Farber 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